PARP10 - Poly [ADP-ribose] polymerase 10 - human protein (Function)
 
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PARP10 »  Poly [ADP-ribose] polymerase 10   [ EC 2.4.2.30 ]  (PARP-10)
 
Protein also known as:  ADP-ribosyltransferase diphtheria toxin-like 10 (ARTD10).
Gene name:  PARP10
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
May play a role in cell proliferation. May be required for the maintenance of cell cycle progression.  
2
  • CuratedUniProtKB
GO molecular function 
K63-linked polyubiquitin bindingdefinition[GO:0070530]  
1
  • IMPUniProtKB
NAD+ ADP-ribosyltransferase activitydefinition[GO:0003950]  
1
  • IMPUniProtKB
Protein bindingdefinition[GO:0005515]  
3
  • IPIIntAct
  • IPIUniProtKB
GO biological process 
Negative regulation of fibroblast proliferationdefinition[GO:0048147]  
1
  • IDAUniProtKB
Negative regulation of gene expressiondefinition[GO:0010629]  
1
  • IMPUniProtKB
Negative regulation of NF-kappaB transcription factor activitydefinition[GO:0032088]  
1
  • IMPUniProtKB
Negative regulation of protein import into nucleus, translocationdefinition[GO:0033159]  
1
  • IMPUniProtKB
Negative regulation of protein K63-linked ubiquitinationdefinition[GO:1900045]  
1
  • IMPUniProtKB
Negative regulation of viral genome replicationdefinition[GO:0045071]  
1
  • IMPUniProtKB
Protein ADP-ribosylationdefinition[GO:0006471]  
1
  • IMPUniProtKB
Protein auto-ADP-ribosylationdefinition[GO:0070213]  
1
  • IMPUniProtKB
Protein poly-ADP-ribosylationdefinition[GO:0070212]  
1
  • IDAUniProtKB
Regulation of chromatin assemblydefinition[GO:0010847]  
1
  • IDAUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.4.2.30: NAD(+) + (ADP-D-ribosyl)(n)-acceptor nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.  
  • CuratedUniProtKB
 

Keywords

Molecular function 
Glycosyltransferase  definition   [KW-0328]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: PARP10
GenomeRNAi: 84875
PRO: PR:Q53GL7