AGK - Acylglycerol kinase, mitochondrial - human protein (Function)
 
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Protein
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References

 
AGK »  Acylglycerol kinase, mitochondrial   [ EC 2.7.1.94EC 2.7.1.107 ]
 
Protein also known as:  Multiple substrate lipid kinase (MuLK).
Gene name:  AGK
Entry whose protein(s) existence is based on evidence at protein level
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1 27 2
GENE REF ISO

Function

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Overview 
Lipid kinase that can phosphorylate both monoacylglycerol and diacylglycerol to form lysophosphatidic acid (LPA) and phosphatidic acid (PA), respectively. Does not phosphorylate sphingosine. Overexpression increases the formation and secretion of LPA, resulting in transactivation of EGFR and activation of the downstream MAPK signaling pathway, leading to increased cell growth.  
1
  • CuratedUniProtKB
GO molecular function 
Acylglycerol kinase activitydefinition[GO:0047620]  
  • IEAEC 2 GO
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Ceramide kinase activitydefinition[GO:0001729] silver  
  • IEAOrtholog Compara
Diacylglycerol kinase activitydefinition[GO:0004143]  
  • IEAEC 2 GO
NAD+ kinase activitydefinition[GO:0003951] silver  
  • IEAInterPro 2 GO
GO biological process 
Ceramide biosynthetic processdefinition[GO:0046513] silver  
  • IEAOrtholog Compara
Glycerolipid metabolic processdefinition[GO:0046486]  
  • IEAUniPathway
Lipid phosphorylationdefinition[GO:0046834] silver  
  • IEAOrtholog Compara
Protein kinase C-activating G-protein coupled receptor signaling pathwaydefinition[GO:0007205] silver  
  • IEAInterPro 2 GO
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reactions
EC 2.7.1.94: ATP + acylglycerol ADP + acyl-sn-glycerol 3-phosphate.  
  • CuratedUniProtKB
EC 2.7.1.107: ATP + 1,2-diacyl-sn-glycerol ADP + 1,2-diacyl-sn-glycerol 3-phosphate.  
  • CuratedUniProtKB
It requires the following cofactor
Magnesium.  
1
  • CuratedUniProtKB
Pathways 
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathways:
Glycerolipid metabolism  hsa00561+55750  
Metabolic pathways  hsa01100+55750  
Note 
Overexpressed in prostate cancer, suggesting that it may play a role in initiation and progression of prostate cancer, processes in which LPA plays key roles.  
  • CuratedUniProtKB
 

Keywords

Molecular function 
Kinase  definition   [KW-0418]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: Q53H12
Other
GeneWiki: AGK_(gene)
GenomeRNAi: 55750
PRO: PR:Q53H12