CYBRD1 - Cytochrome b reductase 1 - human protein (Function)
 
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Protein
Gene
References

 
CYBRD1 »  Cytochrome b reductase 1   [ EC 1.-.-.- ]
 
Protein also known as:  Ferric-chelate reductase 3.
Gene name:  CYBRD1
Entry whose protein(s) existence is based on evidence at protein level
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1 31 3
GENE REF ISO

Function

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Overview 
Ferric-chelate reductase that reduces Fe(3+) to Fe(2+). Present at the brush border of duodenal enterocytes where it probably reduces dietary Fe(3+) thereby facilitating its transport into the mucosal cells. Uses ascorbate as electron donor. May be involved in extracellular ascorbate recycling in erythrocyte membranes. May also act as a ferrireductase in airway epithelial cells.  
4
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the eukaryotic cytochrome b561 (cytb561) family  5.B.2.1.3  
GO molecular function 
Ferric-chelate reductase activitydefinition[GO:0000293]  
1
  • IDAHGNC
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
GO biological process 
Response to iron iondefinition[GO:0010039] silver  
  • IEAOrtholog Compara
Enzymatic activity 
It requires the following cofactor
Binds 2 heme groups non-covalently (By similarity).  
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathway:
Mineral absorption  hsa04978+79901  
According to Reactome, this protein belongs to the following pathway:
Transmembrane transport of small molecules  REACT_15518  
 
More information is available from:
 

Keywords

Biological process 
Electron transport  definition   [KW-0249]
Transport  definition   [KW-0813]
Molecular function 
Oxidoreductase  definition   [KW-0560]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 79901
PRO: PR:Q53TN4