AWAT1 - Acyl-CoA wax alcohol acyltransferase 1 - human protein (Function)
 
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Protein
Gene
References

 
AWAT1 »  Acyl-CoA wax alcohol acyltransferase 1   [ EC 2.3.1.75 ]
 
Protein also known as:  Diacylglycerol O-acyltransferase 2-like protein 3.
Gene name:  AWAT1
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 13 1
GENE REF ISO

Function

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Overview 
Acyltransferase that predominantly esterify long chain (wax) alcohols with acyl-CoA-derived fatty acids to produce wax esters. Wax esters are enriched in sebum, suggesting that it plays a central role in lipid metabolism in skin. Has a preference for arachidyl alcohol as well as decyl alcohol, demonstrating its relatively poor activity using saturated long chain alcohols (C16, C18, and C20).  
1
  • CuratedUniProtKB
GO molecular function 
Long-chain-alcohol O-fatty-acyltransferase activitydefinition[GO:0047196]  
  • IEAEC 2 GO
GO biological process 
Lipid metabolic processdefinition[GO:0006629]  
  • IEAUniProtKB KW
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.3.1.75: Acyl-CoA + a long-chain alcohol CoA + a long-chain ester.  
  • CuratedUniProtKB
 
More information is available from:
 

Biophysicochemical properties

Kinetic parameters
Vmax 113 pmol/min/mg enzyme with [14C]cetyl-CoA as substrate
Vmax 31.7 pmol/min/mg enzyme with [14C]oleoyl-CoA as substrate

Keywords

Biological process 
Lipid biosynthesis  definition   [KW-0444]
Lipid metabolism  definition   [KW-0443]
Molecular function 
Acyltransferase  definition   [KW-0012]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 158833
PRO: PR:Q58HT5