SGOL1 - Shugoshin-like 1 - human protein (Function)
 
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Protein
Gene
References

 
SGOL1 »  Shugoshin-like 1
 
Protein also known as:  Serologically defined breast cancer antigen NY-BR-85.
Gene name:  SGOL1
Family name: Shugoshin
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 47 7
GENE REF ISO

Function

 show evidences
Overview 
Plays a central role in chromosome cohesion during mitosis by preventing premature dissociation of cohesin complex from centromeres after prophase, when most of cohesin complex dissociates from chromosomes arms. May act by preventing phosphorylation of the STAG2 subunit of cohesin complex at the centromere, ensuring cohesin persistence at centromere until cohesin cleavage by ESPL1/separase at anaphase. Essential for proper chromosome segregation during mitosis and this function requires interaction with PPP2R1A. Its phosphorylated form is necessary for chromosome congression and for the proper attachment of spindle microtubule to the kinetochore. Necessary for kinetochore localization of PLK1 and CENPF. May play a role in the tension sensing mechanism of the spindle-assembly checkpoint by regulating PLK1 kinetochore affinity.  
7
  • CuratedUniProtKB
Isoform  Iso 3   Plays a role in maintaining centriole cohesion involved in controlling spindle pole integrity.  
7
  • CuratedUniProtKB
GO molecular function 
Kinase bindingdefinition[GO:0019900]  
1
  • IDAMGI
Protein bindingdefinition[GO:0005515]  
4
  • IPIUniProtKB
  • IPIIntAct
GO biological process 
Attachment of spindle microtubules to kinetochoredefinition[GO:0008608]  
1
  • IDAUniProtKB
Centriole-centriole cohesiondefinition[GO:0010457]  
2
  • IMPMGI
  • IDAUniProtKB
Chromosome segregationdefinition[GO:0007059]  
1
  • IDAUniProtKB
Meiotic chromosome segregationdefinition[GO:0045132]  
1
  • IMPMGI
Mitosisdefinition[GO:0007067]  
  • IEAUniProtKB KW
Pathways 
According to KEGG, this protein belongs to the following pathway:
Oocyte meiosis  hsa04114+151648  
According to Reactome, this protein belongs to the following pathways:
Cell Cycle  REACT_115566  
Mitotic M-M/G1 phases  REACT_21300  
Note 
Shugoshin is Japanese for guardian spirit (as it is known to be a protector of centromeric cohesin).  
  • CuratedUniProtKB
 

Keywords

Biological process 
Cell cycle  definition   [KW-0131]
Cell division  definition   [KW-0132]
Chromosome partition  definition   [KW-0159]
Mitosis  definition   [KW-0498]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: SGOL1
GenomeRNAi: 151648
PRO: PR:Q5FBB7