ACSBG2 - Long-chain-fatty-acid--CoA ligase ACSBG2 - human protein (Function)
 
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ACSBG2 »  Long-chain-fatty-acid--CoA ligase ACSBG2   [ EC 6.2.1.3 ]
 
Protein also known as:  Acyl-CoA synthetase bubblegum family member 2.
Gene name:  ACSBG2
Entry whose protein(s) existence is based on evidence at protein level
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1 21 4
GENE REF ISO

Function

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Overview 
Mediates activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Able to activate long-chain fatty acids. Also able to activate very long-chain fatty acids; however, the relevance of such activity is unclear in vivo. Has increased ability to activate oleic and linoleic acid. May play a role in spermatogenesis.  
  • CuratedUniProtKB
GO molecular function 
Acyl-CoA hydrolase activitydefinition[GO:0047617]  
1
  • IDAMGI
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Long-chain fatty acid-CoA ligase activitydefinition[GO:0004467]  
1
  • IDAMGI
GO biological process 
Cell differentiationdefinition[GO:0030154]  
  • IEAUniProtKB KW
Fatty acid metabolic processdefinition[GO:0006631]  
2
  • IDAMGI
Long-chain fatty acid metabolic processdefinition[GO:0001676]  
1
  • IDAGOC
Multicellular organismal developmentdefinition[GO:0007275]  
  • IEAUniProtKB KW
Spermatogenesisdefinition[GO:0007283]  
  • IEAUniProtKB KW
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 6.2.1.3: ATP + a long-chain fatty acid + CoA AMP + diphosphate + an acyl-CoA.  
2
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Adipocytokine signaling pathway  hsa04920+81616  
Fatty acid metabolism  hsa00071+81616  
Metabolic pathways  hsa01100+81616  
PPAR signaling pathway  hsa03320+81616  
 
More information is available from:
 

Keywords

Biological process 
Differentiation  definition   [KW-0221]
Fatty acid metabolism  definition   [KW-0276]
Lipid metabolism  definition   [KW-0443]
Spermatogenesis  definition   [KW-0744]
Molecular function 
Developmental protein  definition   [KW-0217]
Ligase  definition   [KW-0436]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ACSBG2
GenomeRNAi: 81616
PRO: PR:Q5FVE4