EARS2 - Probable glutamate--tRNA ligase, mitochondrial - human protein (Function)
 
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EARS2 »  Probable glutamate--tRNA ligase, mitochondrial   [ EC 6.1.1.17 ]
 
Protein also known as:  Glutamyl-tRNA synthetase (GluRS).
Gene name:  EARS2
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity).  
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Glutamate-tRNA ligase activitydefinition[GO:0004818]  
1
  • IDAUniProtKB
Glutamate-tRNA(Gln) ligase activitydefinition[GO:0050561]  
1
  • IDAUniProtKB
tRNA bindingdefinition[GO:0000049] silver  
  • IEAInterPro 2 GO
GO biological process 
Glutamyl-tRNA aminoacylationdefinition[GO:0006424]  
1
  • IDAUniProtKB
tRNA aminoacylation for mitochondrial protein translationdefinition[GO:0070127]  
1
  • IDAUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 6.1.1.17: ATP + L-glutamate + tRNA(Glu) AMP + diphosphate + L-glutamyl-tRNA(Glu).  
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Aminoacyl-tRNA biosynthesis  hsa00970+124454  
Metabolic pathways  hsa01100+124454  
Porphyrin and chlorophyll metabolism  hsa00860+124454  
According to Reactome, this protein belongs to the following pathway:
Gene Expression  REACT_71  
 

Keywords

Biological process 
Protein biosynthesis  definition   [KW-0648]
Molecular function 
Aminoacyl-tRNA synthetase  definition   [KW-0030]
Ligase  definition   [KW-0436]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 124454
PRO: PR:Q5JPH6