AMER1 - APC membrane recruitment protein 1 - human protein (Function)
 
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AMER1 »  APC membrane recruitment protein 1  (Amer1)
 
Protein also known as:  Wilms tumor gene on the X chromosome protein.
Gene name:  AMER1
Family name: Amer
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Regulator of the canonical Wnt signaling pathway. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane and interacting with key regulators of the canonical Wnt signaling pathway, such as components of the beta-catenin destruction complex. Acts both as a positive and negative regulator of the Wnt signaling pathway, depending on the context: acts as a positive regulator by promoting LRP6 phosphorylation. Also acts as a negative regulator by acting as a scaffold protein for the beta-catenin destruction complex and promoting stabilization of Axin at the cell membrane. Promotes CTNNB1 ubiquitination and degradation. Involved in kidney development.  
5
  • CuratedUniProtKB
GO molecular function 
Beta-catenin bindingdefinition[GO:0008013]  
1
  • IDAUniProtKB
Phosphatidylinositol-4,5-bisphosphate bindingdefinition[GO:0005546]  
2
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
3
  • IPIIntAct
  • IPIUniProtKB
GO biological process 
Adipose tissue developmentdefinition[GO:0060612] silver  
  • IEAOrtholog Compara
Bone developmentdefinition[GO:0060348] silver  
  • IEAOrtholog Compara
Mesenchymal cell differentiation involved in kidney developmentdefinition[GO:0072161] silver  
  • IEAOrtholog Compara
Negative regulation of canonical Wnt signaling pathwaydefinition[GO:0090090]  
1
  • IMPUniProtKB
Positive regulation of canonical Wnt signaling pathwaydefinition[GO:0090263]  
1
  • IMPUniProtKB
Regulation of canonical Wnt signaling pathwaydefinition[GO:0060828]  
1
  • IMPUniProtKB
Wnt signaling pathwaydefinition[GO:0016055]  
  • IEAUniProtKB KW
Pathways 
According to Reactome, this protein belongs to the following pathways:
Beta-catenin phosphorylation cascade  REACT_11065  
Degradation of beta-catenin by the destruction complex  REACT_11063  
disassembly of the destruction complex and recruitment of AXIN to the membrane  REACT_200610  
Note 
Inactivated in approximately one-third of Wilms tumors.  
  • CuratedUniProtKB
 

Keywords

Biological process 
Wnt signaling pathway  definition   [KW-0879]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 139285
PRO: PR:Q5JTC6