AARS2 - Alanine--tRNA ligase, mitochondrial - human protein (Function)
 
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References

 
AARS2 »  Alanine--tRNA ligase, mitochondrial   [ EC 6.1.1.7 ]
 
Protein also known as:  Alanyl-tRNA synthetase (AlaRS).
Gene name:  AARS2
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 23 1
GENE REF ISO

Function

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Overview 
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain (By similarity).  
  • CuratedUniProtKB
GO molecular function 
Alanine-tRNA ligase activitydefinition[GO:0004813]  
1
  • IMPBHF-UCL
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB Annot
tRNA bindingdefinition[GO:0000049]  
  • IEAUniProtKB KW
Zinc ion bindingdefinition[GO:0008270]  
  • IEAUniProtKB Annot
GO biological process 
Mitochondrial alanyl-tRNA aminoacylationdefinition[GO:0070143]  
1
  • IMPBHF-UCL
Mitochondrial respiratory chain complex assemblydefinition[GO:0033108]  
1
  • IMPBHF-UCL
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 6.1.1.7: ATP + L-alanine + tRNA(Ala) AMP + diphosphate + L-alanyl-tRNA(Ala).  
  • CuratedUniProtKB
It requires the following cofactor
Binds 1 zinc ion per subunit (Potential).  
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathway:
Aminoacyl-tRNA biosynthesis  hsa00970+57505  
According to Reactome, this protein belongs to the following pathway:
Mitochondrial tRNA aminoacylation  REACT_15302  
 

Keywords

Biological process 
Protein biosynthesis  definition   [KW-0648]
Molecular function 
Aminoacyl-tRNA synthetase  definition   [KW-0030]
Ligase  definition   [KW-0436]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: AARS2
GenomeRNAi: 57505
PRO: PR:Q5JTZ9