LRRK2 - Leucine-rich repeat serine/threonine-protein kinase 2 - human protein (Function)
 
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LRRK2 »  Leucine-rich repeat serine/threonine-protein kinase 2   [ EC 2.7.11.1 ]
 
Protein also known as:  Dardarin.
Gene name:  LRRK2
Entry whose protein(s) existence is based on evidence at protein level
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1 463 1
GENE REF ISO

Function

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Overview 
Positively regulates autophagy through a calcium-dependent activation of the CaMKK/AMPK signaling pathway. The process involves activation of nicotinic acid adenine dinucleotide phosphate (NAADP) receptors, increase in lysosomal pH, and calcium release from lysosomes. Together with RAB29, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose 6 phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner. Regulates neuronal process morphology in the intact central nervous system (CNS). Phosphorylates PRDX3. May also have GTPase activity. May play a role in the phosphorylation of proteins central to Parkinson disease.  
  • CuratedUniProtKB
GO molecular function 
Actin bindingdefinition[GO:0003779]  
1
  • IPIParkinsonsUK-UCL
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Clathrin bindingdefinition[GO:0030276]  
1
  • IPIParkinsonsUK-UCL
Enzyme inhibitor activitydefinition[GO:0004857]  
1
  • IDAParkinsonsUK-UCL
Glycoprotein bindingdefinition[GO:0001948]  
1
  • IPIParkinsonsUK-UCL
GTP bindingdefinition[GO:0005525]  
3
  • IDAUniProtKB
  • IDABHF-UCL
GTP-dependent protein kinase activitydefinition[GO:0034211]  
2
  • IDABHF-UCL
  • IMPUniProtKB
GTPase activator activitydefinition[GO:0005096]  
1
  • IDAUniProtKB
GTPase activitydefinition[GO:0003924]  
1
  • IDABHF-UCL
Identical protein bindingdefinition[GO:0042802]  
11
  • IPIIntAct
Ion channel bindingdefinition[GO:0044325]  
1
  • IPIUniProtKB
Kinase activitydefinition[GO:0016301]  
1
  • IDAUniProtKB
MAP kinase kinase activitydefinition[GO:0004708]  
1
  • IDABHF-UCL
Protein bindingdefinition[GO:0005515]  
44
  • IPIIntAct
  • IPIBHF-UCL
Protein homodimerization activitydefinition[GO:0042803]  
1
  • IPIUniProtKB
Protein kinase A bindingdefinition[GO:0051018]  
1
  • IPIParkinsonsUK-UCL
Protein kinase activitydefinition[GO:0004672]  
4
  • IDAUniProtKB
Protein serine/threonine kinase activitydefinition[GO:0004674]  
6
  • IDAParkinsonsUK-UCL
  • IDAMGI
  • IDABHF-UCL
  • IDAUniProtKB
Rho GTPase bindingdefinition[GO:0017048]  
1
  • IPIBHF-UCL
SNARE bindingdefinition[GO:0000149]  
1
  • IPIParkinsonsUK-UCL
Syntaxin-1 bindingdefinition[GO:0017075]  
1
  • IPIParkinsonsUK-UCL
Tubulin bindingdefinition[GO:0015631]  
1
  • IDABHF-UCL
GO biological process 
Activation of MAPK activitydefinition[GO:0000187]  
1
  • IDAGOC
Activation of MAPKK activitydefinition[GO:0000186]  
1
  • IDABHF-UCL
Autophagydefinition[GO:0006914]  
  • IEAUniProtKB KW
Cellular response to organic cyclic compounddefinition[GO:0071407] silver  
  • IEAOrtholog Compara
Determination of adult lifespandefinition[GO:0008340]  
1
  • IMPBHF-UCL
Exploration behaviordefinition[GO:0035640]  
1
  • IMPBHF-UCL
GTP catabolic processdefinition[GO:0006184]  
1
  • IDABHF-UCL
Intracellular distribution of mitochondriadefinition[GO:0048312]  
1
  • IMPBHF-UCL
MAPK cascadedefinition[GO:0000165]  
1
  • IDAUniProtKB
Negative regulation of GTPase activitydefinition[GO:0034260]  
1
  • IDAMGI
Negative regulation of late endosome to lysosome transportdefinition[GO:1902823]  
1
  • TASParkinsonsUK-UCL
Negative regulation of protein bindingdefinition[GO:0032091]  
1
  • IMPParkinsonsUK-UCL
Negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylationdefinition[GO:1903125]  
1
  • IDAParkinsonsUK-UCL
Neuromuscular junction developmentdefinition[GO:0007528]  
1
  • IMPBHF-UCL
Neuron deathdefinition[GO:0070997]  
1
  • IMPBHF-UCL
Neuron projection morphogenesisdefinition[GO:0048812]  
1
  • IMPUniProtKB
Olfactory bulb developmentdefinition[GO:0021772]  
1
  • IMPBHF-UCL
Peptidyl-serine phosphorylationdefinition[GO:0018105]  
1
  • IDABHF-UCL
Peptidyl-threonine phosphorylationdefinition[GO:0018107]  
2
  • IMPParkinsonsUK-UCL
  • IDABHF-UCL
Positive regulation of autophagydefinition[GO:0010508]  
1
  • IMPUniProtKB
  • ISSOrtholog Curator
Positive regulation of dopamine receptor signaling pathwaydefinition[GO:0060161]  
1
  • IMPBHF-UCL
Positive regulation of GTPase activitydefinition[GO:0043547]  
1
  • IDAGOC
  • IEAUniProtKB KW
Positive regulation of programmed cell deathdefinition[GO:0043068]  
1
  • IDAUniProtKB
Positive regulation of proteasomal ubiquitin-dependent protein catabolic processdefinition[GO:0032436]  
  • ISSOrtholog Curator
Positive regulation of protein phosphorylationdefinition[GO:0001934]  
1
  • IMPBHF-UCL
Positive regulation of protein ubiquitinationdefinition[GO:0031398]  
1
  • IDAUniProtKB
Protein autophosphorylationdefinition[GO:0046777]  
5
  • IDAUniProtKB
Regulation of branching morphogenesis of a nervedefinition[GO:2000172]  
1
  • IMPBHF-UCL
Regulation of dendritic spine morphogenesisdefinition[GO:0061001]  
1
  • IMPBHF-UCL
Regulation of kidney sizedefinition[GO:0035564]  
  • ISSOrtholog Curator
Regulation of locomotiondefinition[GO:0040012]  
1
  • IMPBHF-UCL
Regulation of membrane potentialdefinition[GO:0042391]  
1
  • IMPBHF-UCL
Regulation of mitochondrial depolarizationdefinition[GO:0051900]  
1
  • IMPParkinsonsUK-UCL
Regulation of neuroblast proliferationdefinition[GO:1902692]  
1
  • IMPParkinsonsUK-UCL
Regulation of neuron deathdefinition[GO:1901214]  
1
  • IMPParkinsonsUK-UCL
Regulation of neuron maturationdefinition[GO:0014041]  
1
  • IMPBHF-UCL
Regulation of synaptic vesicle exocytosisdefinition[GO:2000300]  
1
  • IMPParkinsonsUK-UCL
Regulation of synaptic vesicle transportdefinition[GO:1902803]  
  • ISSOrtholog Curator
Response to oxidative stressdefinition[GO:0006979]  
1
  • IMPBHF-UCL
Small GTPase mediated signal transductiondefinition[GO:0007264] silver  
  • IEAInterPro 2 GO
Tangential migration from the subventricular zone to the olfactory bulbdefinition[GO:0022028]  
1
  • IMPBHF-UCL
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.1: ATP + a protein ADP + a phosphoprotein.  
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathway:
Parkinson's disease  hsa05012+120892  
 

Keywords

Biological process 
Autophagy  definition   [KW-0072]
Differentiation  definition   [KW-0221]
Molecular function 
GTPase activation  definition   [KW-0343]
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: LRRK2
GenomeRNAi: 120892
PRO: PR:Q5S007
Chemistry
GuidetoPHARMACOLOGY: 2059