LRRK2 - Leucine-rich repeat serine/threonine-protein kinase 2 - human protein (Function)
 
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LRRK2 »  Leucine-rich repeat serine/threonine-protein kinase 2   [ EC 2.7.11.1 ]
 
Protein also known as:  Dardarin.
Gene name:  LRRK2
Entry whose protein(s) existence is based on evidence at protein level
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1 504 1
GENE REF ISO

Function

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Overview 
Positively regulates autophagy through a calcium-dependent activation of the CaMKK/AMPK signaling pathway. The process involves activation of nicotinic acid adenine dinucleotide phosphate (NAADP) receptors, increase in lysosomal pH, and calcium release from lysosomes. Together with RAB29, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose 6 phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner. Regulates neuronal process morphology in the intact central nervous system (CNS). Plays a role in synaptic vesicle trafficking. Phosphorylates PRDX3. Has GTPase activity. May play a role in the phosphorylation of proteins central to Parkinson disease.  
8
  • UniProtKB
GO molecular function 
Actin bindingdefinition[GO:0003779]  
1
  • ParkinsonsUK-UCL
ATP bindingdefinition[GO:0005524]  
1
  • UniProtKB KW
Clathrin bindingdefinition[GO:0030276]  
1
  • ParkinsonsUK-UCL
Glycoprotein bindingdefinition[GO:0001948]  
1
  • ParkinsonsUK-UCL
GTP bindingdefinition[GO:0005525]  
3
  • UniProtKB
  • BHF-UCL
GTP-dependent protein kinase activitydefinition[GO:0034211]  
2
  • BHF-UCL
  • UniProtKB
GTPase activator activitydefinition[GO:0005096]  
1
  • UniProtKB
GTPase activitydefinition[GO:0003924]  
1
  • BHF-UCL
Identical protein bindingdefinition[GO:0042802]  
13
  • IntAct
Ion channel bindingdefinition[GO:0044325]  
2
  • UniProtKB
  • ParkinsonsUK-UCL
Kinase activitydefinition[GO:0016301]  
1
  • UniProtKB
MAP kinase kinase activitydefinition[GO:0004708]  
1
  • BHF-UCL
Peroxidase inhibitor activitydefinition[GO:0036479]  
1
  • ParkinsonsUK-UCL
Protein bindingdefinition[GO:0005515]  
55
  • IntAct
  • BHF-UCL
  • ParkinsonsUK-UCL
Protein homodimerization activitydefinition[GO:0042803]  
1
  • UniProtKB
Protein kinase A bindingdefinition[GO:0051018]  
1
  • ParkinsonsUK-UCL
Protein kinase activitydefinition[GO:0004672]  
4
  • UniProtKB
Protein serine/threonine kinase activitydefinition[GO:0004674]  
6
  • ParkinsonsUK-UCL
  • MGI
  • BHF-UCL
  • UniProtKB
Rho GTPase bindingdefinition[GO:0017048]  
1
  • BHF-UCL
SNARE bindingdefinition[GO:0000149]  
1
  • ParkinsonsUK-UCL
Syntaxin-1 bindingdefinition[GO:0017075]  
1
  • ParkinsonsUK-UCL
Tubulin bindingdefinition[GO:0015631]  
1
  • BHF-UCL
GO biological process 
Activation of MAPK activitydefinition[GO:0000187]  
1
  • ParkinsonsUK-UCL
Activation of MAPKK activitydefinition[GO:0000186]  
1
  • BHF-UCL
Autophagydefinition[GO:0006914]  
1
  • UniProtKB KW
Cellular protein localizationdefinition[GO:0034613]  
1
  • Ortholog Curator
Cellular response to dopaminedefinition[GO:1903351]  
1
  • ParkinsonsUK-UCL
Cellular response to manganese iondefinition[GO:0071287]  
1
  • ParkinsonsUK-UCL
Cellular response to oxidative stressdefinition[GO:0034599]  
3
  • ParkinsonsUK-UCL
Determination of adult lifespandefinition[GO:0008340]  
1
  • BHF-UCL
Endocytosisdefinition[GO:0006897]  
2
  • ParkinsonsUK-UCL
Exploration behaviordefinition[GO:0035640]  
1
  • BHF-UCL
Intracellular distribution of mitochondriadefinition[GO:0048312]  
1
  • BHF-UCL
Intracellular signal transductiondefinition[GO:0035556]  
1
  • Ortholog Curator
Locomotory exploration behaviordefinition[GO:0035641] silver  
1
  • Ortholog Compara
MAPK cascadedefinition[GO:0000165]  
1
  • UniProtKB
Mitochondrion localizationdefinition[GO:0051646]  
1
  • ParkinsonsUK-UCL
Mitochondrion organizationdefinition[GO:0007005]  
1
  • ParkinsonsUK-UCL
Negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathwaydefinition[GO:1902236]  
1
  • ParkinsonsUK-UCL
Negative regulation of GTPase activitydefinition[GO:0034260]  
1
  • MGI
Negative regulation of hydrogen peroxide-induced cell deathdefinition[GO:1903206]  
1
  • ParkinsonsUK-UCL
Negative regulation of late endosome to lysosome transportdefinition[GO:1902823]  
1
  • ParkinsonsUK-UCL
Negative regulation of neuron deathdefinition[GO:1901215]  
1
  • ParkinsonsUK-UCL
Negative regulation of peroxidase activitydefinition[GO:2000469]  
1
  • GOC
Negative regulation of protein bindingdefinition[GO:0032091]  
1
  • ParkinsonsUK-UCL
Negative regulation of protein phosphorylationdefinition[GO:0001933]  
1
  • Ortholog Curator
Negative regulation of protein processingdefinition[GO:0010955]  
1
  • ParkinsonsUK-UCL
Negative regulation of protein processing involved in protein targeting to mitochondriondefinition[GO:1903217]  
1
  • ParkinsonsUK-UCL
Negative regulation of protein targeting to mitochondriondefinition[GO:1903215]  
1
  • ParkinsonsUK-UCL
Negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylationdefinition[GO:1903125]  
1
  • ParkinsonsUK-UCL
Neuromuscular junction developmentdefinition[GO:0007528]  
1
  • BHF-UCL
Neuron deathdefinition[GO:0070997]  
1
  • BHF-UCL
Neuron projection morphogenesisdefinition[GO:0048812]  
1
  • UniProtKB
Olfactory bulb developmentdefinition[GO:0021772]  
1
  • ParkinsonsUK-UCL
Peptidyl-serine phosphorylationdefinition[GO:0018105]  
1
  • BHF-UCL
Peptidyl-threonine phosphorylationdefinition[GO:0018107]  
2
  • ParkinsonsUK-UCL
  • BHF-UCL
Positive regulation of autophagydefinition[GO:0010508]  
2
  • UniProtKB
  • Ortholog Curator
Positive regulation of dopamine receptor signaling pathwaydefinition[GO:0060161]  
1
  • BHF-UCL
Positive regulation of GTPase activitydefinition[GO:0043547]  
2
  • GOC
  • UniProtKB KW
Positive regulation of MAP kinase activitydefinition[GO:0043406]  
1
  • ParkinsonsUK-UCL
Positive regulation of programmed cell deathdefinition[GO:0043068]