LRRK2 - Leucine-rich repeat serine/threonine-protein kinase 2 - human protein (Medical)
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LRRK2 »  Leucine-rich repeat serine/threonine-protein kinase 2   [ EC ]
Protein also known as:  Dardarin.
Gene name:  LRRK2
Entry whose protein(s) existence is based on evidence at protein level
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1 443 1

Displayed isoform: Iso 1



 show evidences
Parkinson disease 8 (PARK8) [MIM:607060]: A slowly progressive neurodegenerative disorder characterized by bradykinesia, rigidity, resting tremor, postural instability, neuronal loss in the substantia nigra, and the presence of neurofibrillary MAPT (tau)-positive and Lewy bodies in some patients. The disease is caused by mutations affecting the gene represented in this entry.  
  • CuratedUniProtKB
According to Orphanet, this protein is involved in the following disease:
Young adult-onset Parkinsonism  2828  


Disease mutation  definition   [KW-0225]
Neurodegeneration  definition   [KW-0523]
Parkinson disease  definition   [KW-0907]
Parkinsonism  definition   [KW-0908]
Technical term 
Reference proteome  definition   [KW-1185]

Further external links

Organism-specific databases
CTD: 120892
MIM: 607060
MIM: 168600
PharmGKB: PA134968052
Polymorphism databases
DMDM: 294862450
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.