ATAT1 - Alpha-tubulin N-acetyltransferase - human protein (Function)
 
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ATAT1 »  Alpha-tubulin N-acetyltransferase   [ EC 2.3.1.108 ]  (TAT)
 
Protein also known as:  Acetyltransferase mec-17 homolog.
Gene name:  ATAT1
Family name: UPF0635
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. May affect microtubule stability and regulate microtubule dynamics. May be involved in neuron development.  
1
  • CuratedUniProtKB
GO molecular function 
Tubulin N-acetyltransferase activitydefinition[GO:0019799]  
1
  • IMPUniProtKB
GO biological process 
Alpha-tubulin acetylationdefinition[GO:0071929] silver  
  • IEAInterPro 2 GO
Neuron developmentdefinition[GO:0048666]  
  • IEAUniProtKB Annot
Regulation of microtubule cytoskeleton organizationdefinition[GO:0070507]  
  • IEAUniProtKB Annot
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.3.1.108: Acetyl-CoA + [alpha-tubulin]-L-lysine CoA + [alpha-tubulin]-N(6)-acetyl-L-lysine.  
1
  • CuratedUniProtKB
 

Keywords

Molecular function 
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 79969
PRO: PR:Q5SQI0