CELF3 - CUGBP Elav-like family member 3 - human protein (Function)
 
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CELF3 »  CUGBP Elav-like family member 3
 
Gene name:  CELF3
Family name: CELF/BRUNOL
Entry whose protein(s) existence is based on evidence at protein level
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1 19 4
GENE REF ISO

Function

 show evidences
Overview 
RNA-binding protein involved in the regulation of pre-mRNA alternative splicing. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Activates the splicing of MAPT/Tau exon 10. Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA.  
2
  • CuratedUniProtKB
GO molecular function 
mRNA bindingdefinition[GO:0003729]  
1
  • NASUniProtKB
Nucleotide bindingdefinition[GO:0000166] silver  
  • IEAInterPro 2 GO
RNA bindingdefinition[GO:0003723]  
1
  • IMPUniProtKB
GO biological process 
mRNA splicing, via spliceosomedefinition[GO:0000398]  
1
  • NASUniProtKB
Positive regulation of mRNA splicing, via spliceosomedefinition[GO:0048026]  
1
  • IDAUniProtKB
Regulation of alternative mRNA splicing, via spliceosomedefinition[GO:0000381]  
1
  • IDAUniProtKB
RNA splicingdefinition[GO:0008380]  
1
  • IMPUniProtKB
Sperm motilitydefinition[GO:0030317] silver  
  • IEAOrtholog Compara
Spermatogenesisdefinition[GO:0007283] silver  
  • IEAOrtholog Compara
 

Keywords

Biological process 
mRNA processing  definition   [KW-0507]
mRNA splicing  definition   [KW-0508]
Molecular function 
Activator  definition   [KW-0010]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 11189
PRO: PR:Q5SZQ8