BEND3 - BEN domain-containing protein 3 - human protein (Function)
 
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Protein
Gene
References

 
BEND3 »  BEN domain-containing protein 3
 
Gene name:  BEND3
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Transcriptional repressor which associates with the NoRC (nucleolar remodeling complex) complex and plays a key role in repressing rDNA transcription. The sumoylated form modulates the stability of the NoRC complex component BAZ2A/TIP5 by controlling its USP21-mediated deubiquitination (PubMed21914818, PubMed26100909). Binds to unmethylated major satellite DNA and is involved in the recruitment of the Polycomb repressive complex 2 (PRC2) to major satellites (By similarity).  
4
  • UniProtKB
GO molecular function 
Protein bindingdefinition[GO:0005515]  
3
  • UniProtKB
  • IntAct
rDNA bindingdefinition[GO:0000182]  
1
  • UniProtKB
GO biological process 
Chromatin silencing at rDNAdefinition[GO:0000183]  
1
  • UniProtKB
DNA methylationdefinition[GO:0006306]  
1
  • UniProtKB
Histone H3-K27 trimethylationdefinition[GO:0098532]  
1
  • UniProtKB
Histone H3-K4 trimethylationdefinition[GO:0080182]  
1
  • UniProtKB
Histone H3-K9 trimethylationdefinition[GO:0036124]  
1
  • UniProtKB
Histone H4 acetylationdefinition[GO:0043967]  
1
  • UniProtKB
Histone H4-K20 trimethylationdefinition[GO:0034773]  
1
  • UniProtKB
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122]  
1
  • UniProtKB
Transcription, DNA-templateddefinition[GO:0006351]  
1
  • UniProtKB KW
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Chromatin regulator  definition   [KW-0156]
Repressor  definition   [KW-0678]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 57673
PRO: PR:Q5T5X7