PHF19 - PHD finger protein 19 - human protein (Function)
 
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Protein
Gene
References

 
PHF19 »  PHD finger protein 19
 
Protein also known as:  Polycomb-like protein 3.
Gene name:  PHF19
Family name: Polycomblike
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 22 3
GENE REF ISO

Function

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Overview 
Polycomb group (PcG) that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex. Probably involved in the transition from an active state to a repressed state in embryonic stem cells: acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting H3K36me3 histone demethylases NO66 or KDM2B, leading to demethylation of H3K36 and recruitment of the PRC2 complex that mediates H3K27me3 methylation, followed by de novo silencing. Recruits the PRC2 complex to CpG islands and contributes to embryonic stem cell self-renewal. Also binds dimethylated at 'Lys-36' (H3K36me2).  
4
  • CuratedUniProtKB
Isoforms  Iso 1 and Iso 2   Inhibit transcription from an HSV-tk promoter.  
4
  • CuratedUniProtKB
GO molecular function 
Methylated histone bindingdefinition[GO:0035064]  
3
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
3
  • IPIIntAct
  • IPIUniProtKB
Zinc ion bindingdefinition[GO:0008270] silver  
  • IEAInterPro 2 GO
GO biological process 
Chromatin modificationdefinition[GO:0016568]  
  • IEAUniProtKB KW
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122] silver  
  • IEAOrtholog Compara
Positive regulation of histone H3-K27 methylationdefinition[GO:0061087]  
1
  • IMPUniProtKB
Stem cell maintenancedefinition[GO:0019827] silver  
  • IEAOrtholog Compara
Transcription, DNA-templateddefinition[GO:0006351]  
  • IEAUniProtKB KW
Pathways 
According to Reactome, this protein belongs to the following pathway:
PRC2 methylates histones and DNA  REACT_200808  
Note 
Down-regulated in spheroid melanoma cells that display an invasive phenotype, characterized by a higher motility, a poor proliferation rate and a gain of pluripotency gene expression. PHF19 favors the proliferation and reduces the transmigration capacity of melanoma cell lines, 2 properties of invasive cells, suggesting that down-regulation may participate in the switch from proliferative to invasive states in melanoma cells (PubMed22487681).  
1
  • CuratedUniProtKB
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Chromatin regulator  definition   [KW-0156]
Repressor  definition   [KW-0678]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 26147
PRO: PR:Q5T6S3