WLS - Protein wntless homolog - human protein (Function)
 
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Protein
Gene
References

 
WLS »  Protein wntless homolog
 
Protein also known as:  Putative NF-kappa-B-activating protein 373.
Gene name:  WLS
Family name: Wntless
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 44 3
GENE REF ISO

Function

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Overview 
Regulates Wnt proteins sorting and secretion in a feedback regulatory mechanism. This reciprocal interaction plays a key role in the regulation of expression, subcellular location, binding and organelle-specific association of Wnt proteins. Plays also an important role in establishment of the anterior-posterior body axis formation during development (By similarity).  
3
  • UniProtKB
According to TCDB this is a transporter from family:
the wntless protein (wls) family  8.A.56.1.2  
GO molecular function 
Mu-type opioid receptor bindingdefinition[GO:0031852] silver  
1
  • Ortholog Compara
Protein bindingdefinition[GO:0005515]  
3
  • IntAct
  • ParkinsonsUK-UCL
Signal transducer activitydefinition[GO:0004871]  
1
  • Ortholog Curator
Wnt-protein bindingdefinition[GO:0017147]  
1
  • ParkinsonsUK-UCL
GO biological process 
Anterior/posterior axis specificationdefinition[GO:0009948] silver  
1
  • Ortholog Compara
Intracellular protein transportdefinition[GO:0006886]  
1
  • ParkinsonsUK-UCL
Mesoderm formationdefinition[GO:0001707] silver  
1
  • Ortholog Compara
Positive regulation of canonical Wnt signaling pathwaydefinition[GO:0090263]  
1
  • BHF-UCL
Positive regulation of I-kappaB kinase/NF-kappaB signalingdefinition[GO:0043123]  
1
  • Ortholog Curator
Positive regulation of Wnt protein secretiondefinition[GO:0061357]  
2
  • ParkinsonsUK-UCL
Positive regulation of Wnt signaling pathwaydefinition[GO:0030177]  
2
  • ParkinsonsUK-UCL
Wnt signaling pathwaydefinition[GO:0016055] silver  
1
  • Ortholog Compara
Pathways 
According to Reactome, this protein belongs to the following pathway:
WNT ligand biogenesis and trafficking  R-HSA-3238698  
 

Keywords

Biological process 
Wnt signaling pathway  definition   [KW-0879]
Molecular function 
Developmental protein  definition   [KW-0217]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: GPR177
GenomeRNAi: 79971
PRO: PR:Q5T9L3