HES5 - Transcription factor HES-5 - human protein (Function)
 
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Protein
Gene
References

 
HES5 »  Transcription factor HES-5
 
Protein also known as:  Class B basic helix-loop-helix protein 38 (bHLHb38).
Gene name:  HES5
Entry whose protein(s) existence is based on evidence at protein level
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1 22 1
GENE REF ISO

Function

 show evidences
Overview 
Transcriptional repressor of genes that require a bHLH protein for their transcription. Plays an important role as neurogenesis negative regulator (By similarity).  
  • CuratedUniProtKB
GO molecular function 
Chromatin bindingdefinition[GO:0003682] silver  
  • IEAOrtholog Compara
Double-stranded DNA bindingdefinition[GO:0003690] silver  
  • IEAOrtholog Compara
Protein dimerization activitydefinition[GO:0046983] silver  
  • IEAInterPro 2 GO
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcriptiondefinition[GO:0001078]  
  • ISSOrtholog Curator
Transcription factor bindingdefinition[GO:0008134]  
1
  • NASUniProtKB
GO biological process 
Astrocyte differentiationdefinition[GO:0048708]  
  • ISSOrtholog Curator
Auditory receptor cell differentiationdefinition[GO:0042491]  
  • ISSOrtholog Curator
Auditory receptor cell fate determinationdefinition[GO:0042668] silver  
  • IEAOrtholog Compara
Brain developmentdefinition[GO:0007420]  
  • ISSOrtholog Curator
Camera-type eye developmentdefinition[GO:0043010]  
  • ISSOrtholog Curator
Cartilage developmentdefinition[GO:0051216]  
1
  • IDAUniProtKB
Cell adhesiondefinition[GO:0007155]  
  • ISSOrtholog Curator
Cell maturationdefinition[GO:0048469]  
  • ISSOrtholog Curator
Central nervous system myelinationdefinition[GO:0022010]  
  • ISSOrtholog Curator
Not  Chondrocyte differentiationdefinition[GO:0002062]  
  • ISSOrtholog Curator
Comma-shaped body morphogenesisdefinition[GO:0072049] silver  
  • IEAOrtholog Compara
Forebrain radial glial cell differentiationdefinition[GO:0021861] silver  
  • IEAOrtholog Compara
Glial cell fate commitmentdefinition[GO:0021781]  
  • ISSOrtholog Curator
Metanephric nephron tubule morphogenesisdefinition[GO:0072282] silver  
  • IEAOrtholog Compara
Negative regulation of astrocyte differentiationdefinition[GO:0048712]  
  • ISSOrtholog Curator
Negative regulation of forebrain neuron differentiationdefinition[GO:2000978] silver  
  • IEAOrtholog Compara
Negative regulation of inner ear receptor cell differentiationdefinition[GO:2000981] silver  
  • IEAOrtholog Compara
Negative regulation of neuron differentiationdefinition[GO:0045665]  
  • ISSOrtholog Curator
Negative regulation of oligodendrocyte differentiationdefinition[GO:0048715]  
  • ISSOrtholog Curator
Negative regulation of pro-B cell differentiationdefinition[GO:2000974]  
  • ISSOrtholog Curator
Negative regulation of stem cell differentiationdefinition[GO:2000737]  
1
  • IMPUniProtKB
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122]  
  • ISSOrtholog Curator
Neural tube developmentdefinition[GO:0021915]  
  • ISSOrtholog Curator
Neuronal stem cell maintenancedefinition[GO:0097150]  
1
  • IEPUniProtKB
Notch signaling pathwaydefinition[GO:0007219]  
2
  • IMPUniProtKB
Oligodendrocyte developmentdefinition[GO:0014003]  
  • ISSOrtholog Curator
Positive regulation of BMP signaling pathwaydefinition[GO:0030513]  
  • ISSOrtholog Curator
Positive regulation of cell proliferationdefinition[GO:0008284]  
1
  • IMPUniProtKB
Positive regulation of JAK-STAT cascadedefinition[GO:0046427]  
  • ISSOrtholog Curator
Positive regulation of Notch signaling pathwaydefinition[GO:0045747] silver  
  • IEAOrtholog Compara
Positive regulation of smooth muscle cell proliferationdefinition[GO:0048661]  
1
  • IGIUniProtKB
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944] silver  
  • IEAOrtholog Compara
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
  • ISSOrtholog Curator
Positive regulation of tyrosine phosphorylation of Stat3 proteindefinition[GO:0042517]  
  • ISSOrtholog Curator
Protein complex assemblydefinition[GO:0006461]  
  • ISSOrtholog Curator
Regulation of cell differentiationdefinition[GO:0045595]  
  • ISSOrtholog Curator
Regulation of myelinationdefinition[GO:0031641]  
  • ISSOrtholog Curator
Regulation of neurogenesisdefinition[GO:0050767]  
  • ISSOrtholog Curator
S-shaped body morphogenesisdefinition[GO:0072050] silver  
  • IEAOrtholog Compara
Smoothened signaling pathwaydefinition[GO:0007224]  
  • ISSOrtholog Curator
Specification of loop of Henle identitydefinition[GO:0072086] silver  
  • IEAOrtholog Compara
Telencephalon developmentdefinition[GO:0021537]  
  • ISSOrtholog Curator
Transcription, DNA-templateddefinition[GO:0006351]  
  • IEAUniProtKB KW
Pathways 
According to KEGG, this protein belongs to the following pathway:
Notch signaling pathway  hsa04330+388585  
According to Reactome, this protein belongs to the following pathways:
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants  REACT_160254  
Constitutive Signaling by NOTCH1 PEST Domain Mutants  REACT_160243  
NOTCH1 Intracellular Domain Regulates Transcription  REACT_118780  
NOTCH2 intracellular domain regulates transcription  REACT_163910  
 

Keywords

Biological process 
Differentiation  definition   [KW-0221]
Neurogenesis  definition   [KW-0524]
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Developmental protein  definition   [KW-0217]
Repressor  definition   [KW-0678]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: HES5
GenomeRNAi: 388585
PRO: PR:Q5TA89