RNASEH2B - Ribonuclease H2 subunit B - human protein (Function)
 
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RNASEH2B »  Ribonuclease H2 subunit B  (RNase H2 subunit B)
 
Protein also known as:  Aicardi-Goutieres syndrome 2 protein (AGS2).
Gene name:  RNASEH2B
Family name: RNase H2 subunit B
Entry whose protein(s) existence is based on evidence at protein level
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1 30 2
GENE REF ISO

Function

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Overview 
Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.  
2
  • CuratedUniProtKB
GO molecular function 
RNA-DNA hybrid ribonuclease activitydefinition[GO:0004523] silver  
  • IEAOrtholog Compara
GO biological process 
In utero embryonic developmentdefinition[GO:0001701] silver  
  • IEAOrtholog Compara
Negative regulation of gene expressiondefinition[GO:0010629] silver  
  • IEAOrtholog Compara
Positive regulation of fibroblast proliferationdefinition[GO:0048146] silver  
  • IEAOrtholog Compara
Regulation of DNA damage checkpointdefinition[GO:2000001] silver  
  • IEAOrtholog Compara
Regulation of G2/M transition of mitotic cell cycledefinition[GO:0010389] silver  
  • IEAOrtholog Compara
Ribonucleotide metabolic processdefinition[GO:0009259] silver  
  • IEAOrtholog Compara
RNA catabolic processdefinition[GO:0006401]  
1
  • IDAUniProtKB
RNA phosphodiester bond hydrolysis, endonucleolyticdefinition[GO:0090502]  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathway:
DNA replication  hsa03030+79621  
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 79621
PRO: PR:Q5TBB1