MLK4 - Mitogen-activated protein kinase kinase kinase MLK4 - human protein (Function)
 
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MLK4 »  Mitogen-activated protein kinase kinase kinase MLK4   [ EC 2.7.11.25 ]
 
Protein also known as:  Mixed lineage kinase 4.
Gene name:  MLK4
Entry whose protein(s) existence is based on evidence at protein level
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1 31 3
GENE REF ISO

Function

 show evidences
Overview 
Negative regulator of TLR4 signaling. Does not activate JNK1/MAPK8 pathway, p38/MAPK14, nor ERK2/MAPK1 pathways.  
1
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
MAP kinase kinase kinase activitydefinition[GO:0004709]  
  • IEAEC 2 GO
Protein homodimerization activitydefinition[GO:0042803]  
  • ISSOrtholog Curator
Protein tyrosine kinase activitydefinition[GO:0004713] silver  
  • IEAInterPro 2 GO
GO biological process 
Activation of JUN kinase activitydefinition[GO:0007257]  
  • ISSOrtholog Curator
Protein autophosphorylationdefinition[GO:0046777]  
  • ISSOrtholog Curator
Protein phosphorylationdefinition[GO:0006468]  
  • ISSOrtholog Curator
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.25: ATP + a protein ADP + a phosphoprotein.  
  • CuratedUniProtKB
It requires the following cofactor
Magnesium (By similarity).  
  • CuratedUniProtKB
It is regulated in the following manner
Homodimerization via the leucine zipper domains is required for autophosphorylation and subsequent activation (By similarity).  
  • CuratedUniProtKB
 

Keywords

Molecular function 
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 84451
PRO: PR:Q5TCX8