TTBK1 - Tau-tubulin kinase 1 - human protein (Function)
 
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Protein
Gene
References

 
TTBK1 »  Tau-tubulin kinase 1   [ EC 2.7.11.1 ]
 
Protein also known as:  Brain-derived tau kinase.
Gene name:  TTBK1
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Serine/threonine kinase which is able to phosphorylate TAU on serine, threonine and tyrosine residues. Induces aggregation of TAU.  
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  • UniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
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  • UniProtKB KW
Protein serine/threonine kinase activitydefinition[GO:0004674]  
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  • RefGenome
GO biological process 
Peptidyl-serine phosphorylationdefinition[GO:0018105]  
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  • RefGenome
Regulation of cell shapedefinition[GO:0008360]  
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  • RefGenome
Substantia nigra developmentdefinition[GO:0021762]  
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  • UniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.1: ATP + a protein ADP + a phosphoprotein.  
2
  • UniProtKB
It requires the following cofactor
 Mg(2+) : Divalent metal cations. Mg(2+) or, to a lesser extent, Mn(2+), but not Ca(2+) or Zn(2+).  
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  • UniProtKB
 

Keywords

Molecular function 
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 84630
PRO: PR:Q5TCY1