SH3PXD2A - SH3 and PX domain-containing protein 2A - human protein (Function)
 
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SH3PXD2A »  SH3 and PX domain-containing protein 2A
 
Protein also known as:  Tyrosine kinase substrate with five SH3 domains.
Gene name:  SH3PXD2A
Family name: SH3PXD2
Entry whose protein(s) existence is based on evidence at protein level
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1 41 3
GENE REF ISO

Function

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Overview 
Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. In association with ADAM12, mediates the neurotoxic effect of beta-amyloid peptide.  
5
  • CuratedUniProtKB
GO molecular function 
Phosphatidylinositol bindingdefinition[GO:0035091] silver  
  • IEAInterPro 2 GO
Protein bindingdefinition[GO:0005515]  
4
  • IPIUniProtKB
  • IPIIntAct
GO biological process 
Superoxide metabolic processdefinition[GO:0006801]  
2
  • IMPUniProtKB
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: SH3PXD2A
GenomeRNAi: 9644
PRO: PR:Q5TCZ1