OBSCN - Obscurin - human protein (Function)
 
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OBSCN »  Obscurin   [ EC 2.7.11.1 ]
 
Protein also known as:  Obscurin-myosin light chain kinase (Obscurin-MLCK).
Gene name:  OBSCN
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 62 5
GENE REF ISO

Function

 show evidences
Overview 
Involved in myofibrillogenesis. Seems to be involved in assembly of myosin into sarcomeric A bands in striated muscle.  
2
  • CuratedUniProtKB
Isoform  Iso 3   Together with ANK1 isoform Mu17/Ank1.5 may provide a molecular link between the sarcoplasmic reticulum and myofibrils.  
2
  • CuratedUniProtKB
GO molecular function 
Ankyrin bindingdefinition[GO:0030506]  
1
  • IPIBHF-UCL
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Calmodulin bindingdefinition[GO:0005516]  
  • IEAUniProtKB KW
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Protein bindingdefinition[GO:0005515]  
5
  • IPIIntAct
Protein serine/threonine kinase activitydefinition[GO:0004674]  
  • IEAUniProtKB KW
Protein tyrosine kinase activitydefinition[GO:0004713] silver  
  • IEAInterPro 2 GO
Rho guanyl-nucleotide exchange factor activitydefinition[GO:0005089] silver  
  • IEAInterPro 2 GO
Structural constituent of muscledefinition[GO:0008307]  
1
  • NASBHF-UCL
Titin bindingdefinition[GO:0031432]  
1
  • IPIBHF-UCL
GO biological process 
Multicellular organismal developmentdefinition[GO:0007275]  
  • IEAUniProtKB KW
Peptidyl-tyrosine phosphorylationdefinition[GO:0018108]  
  • IEAInterPro 2 GO
Positive regulation of Rho GTPase activitydefinition[GO:0032321]  
  • IEAInterPro 2 GO
Protein localization to M-banddefinition[GO:0036309]  
1
  • ISSBHF-UCL
Sarcomere organizationdefinition[GO:0045214]  
1
  • TASBHF-UCL
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.1: ATP + a protein ADP + a phosphoprotein.  
  • CuratedUniProtKB
It requires the following cofactor
Magnesium (By similarity).  
  • CuratedUniProtKB
Pathways 
According to Reactome, this protein belongs to the following pathways:
G alpha (12/13) signalling events  REACT_18407  
NRAGE signals death through JNK  REACT_13638  
Rho GTPase cycle  REACT_11051  
Caution 
Initially the name obscurin was used to describe isoform 3 which lacks the kinase domains.  
  • CuratedUniProtKB
 

Keywords

Biological process 
Differentiation  definition   [KW-0221]
Molecular function 
Developmental protein  definition   [KW-0217]
Kinase  definition   [KW-0418]
Muscle protein  definition   [KW-0514]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Obscurin
GeneWiki: OBSCN
GenomeRNAi: 84033
PRO: PR:Q5VST9