CDC42BPA - Serine/threonine-protein kinase MRCK alpha - human protein (Function)
 
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CDC42BPA »  Serine/threonine-protein kinase MRCK alpha
 
Gene name:  CDC42BPA
Entry whose protein(s) existence is based on evidence at protein level
extend overview
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GENE REF ISO

Function

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Overview 
Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2. In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. Phosphorylates: PPP1R12A, LIMK1 and LIMK2. May play a role in TFRC-mediated iron uptake.  
8
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
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  • IDAUniProtKB
Identical protein bindingdefinition[GO:0042802]  
2
  • IPIIntAct
Magnesium ion bindingdefinition[GO:0000287]  
1
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
3
  • IPIIntAct
Protein serine/threonine kinase activitydefinition[GO:0004674]  
4
  • IDAUniProtKB
Small GTPase regulator activitydefinition[GO:0005083] silver  
  • IEAInterPro 2 GO
GO biological process 
Actin cytoskeleton reorganizationdefinition[GO:0031532]  
1
  • IDAUniProtKB
Actomyosin structure organizationdefinition[GO:0031032]  
1
  • IMPUniProtKB
Cell migrationdefinition[GO:0016477]  
1
  • IMPUniProtKB
Intracellular signal transductiondefinition[GO:0035556] silver  
  • IEAInterPro 2 GO
Microtubule cytoskeleton organizationdefinition[GO:0000226] silver  
  • IEAOrtholog Compara
Nuclear migrationdefinition[GO:0007097] silver  
  • IEAOrtholog Compara
Protein phosphorylationdefinition[GO:0006468]  
1
  • IDAUniProtKB
Regulation of catalytic activitydefinition[GO:0050790]  
  • IEAInterPro 2 GO
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.1: ATP + a protein ADP + a phosphoprotein.  
1
  • CuratedUniProtKB
It requires the following cofactor
Magnesium.  
1
  • CuratedUniProtKB
It is regulated in the following manner
Maintained in an inactive, closed conformation by an interaction between the kinase domain and the negative autoregulatory C-terminal coiled-coil region. Agonist binding to the phorbol ester binding site disrupts this, releasing the kinase domain to allow N-terminus-mediated dimerization and kinase activation by transautophosphorylation. Inhibited by chelerythrine chloride.  
2
  • CuratedUniProtKB
 

Keywords

Molecular function 
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: CDC42BPA
GenomeRNAi: 8476
PRO: PR:Q5VT25
Chemistry
GuidetoPHARMACOLOGY: 1507