RNF220 - E3 ubiquitin-protein ligase RNF220 - human protein (Function)
 
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Protein
Gene
References

 
RNF220 »  E3 ubiquitin-protein ligase RNF220   [ EC 6.3.2.- ]
 
Protein also known as:  RING finger protein 220.
Gene name:  RNF220
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of SIN3B (By similarity). Independently of its E3 ligase activity, acts as a CTNNB1 stabilizer through USP7-mediated deubiquitination of CTNNB1 promoting Wnt signaling (PubMed25266658).  
3
  • UniProtKB
GO molecular function 
Ligase activitydefinition[GO:0016874]  
1
  • UniProtKB KW
Protein bindingdefinition[GO:0005515]  
1
  • UniProtKB
Ubiquitin-protein transferase activitydefinition[GO:0004842]  
1
  • Ortholog Curator
Zinc ion bindingdefinition[GO:0008270] silver  
1
  • InterPro 2 GO
GO biological process 
Positive regulation of canonical Wnt signaling pathwaydefinition[GO:0090263]  
1
  • UniProtKB
Protein autoubiquitinationdefinition[GO:0051865]  
1
  • Ortholog Curator
Protein ubiquitinationdefinition[GO:0016567]  
1
  • Ortholog Curator
Pathways 
This protein is involved in the following pathway
Protein modification; protein ubiquitination  
1
  • UniProtKB
According to Reactome, this protein belongs to the following pathway:
Antigen processing: Ubiquitination & Proteasome degradation  REACT_75842  
 

Keywords

Biological process 
Ubl conjugation pathway  definition   [KW-0833]
Molecular function 
Ligase  definition   [KW-0436]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: RNF220
GenomeRNAi: 55182
PRO: PR:Q5VTB9