ARHGEF16 - Rho guanine nucleotide exchange factor 16 - human protein (Function)
 
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Protein
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References

 
ARHGEF16 »  Rho guanine nucleotide exchange factor 16
 
Protein also known as:  Ephexin-4.
Gene name:  ARHGEF16
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Guanyl-nucleotide exchange factor of the RHOG GTPase stimulating the exchange of RHOG-associated GDP for GTP. May play a role in chemotactic cell migration by mediating the activation of RAC1 by EPHA2. May also activate CDC42 and mediate activation of CDC42 by the viral protein HPV16 E6.  
1
  • CuratedUniProtKB
GO molecular function 
PDZ domain bindingdefinition[GO:0030165]  
1
  • IPIBHF-UCL
Protein bindingdefinition[GO:0005515]  
1
  • IPIUniProtKB
Receptor tyrosine kinase bindingdefinition[GO:0030971]  
1
  • IPIUniProtKB
Rho GTPase bindingdefinition[GO:0017048]  
1
  • IPIUniProtKB
Rho guanyl-nucleotide exchange factor activitydefinition[GO:0005089]  
1
  • IDAUniProtKB
GO biological process 
Activation of Cdc42 GTPase activitydefinition[GO:0032864]  
1
  • IDABHF-UCL
Activation of Rac GTPase activitydefinition[GO:0032863]  
1
  • IMPUniProtKB
Cell chemotaxisdefinition[GO:0060326]  
1
  • IMPUniProtKB
Positive regulation of establishment of protein localization to plasma membranedefinition[GO:0090004]  
1
  • IMPUniProtKB
Pathways 
According to Reactome, this protein belongs to the following pathways:
G alpha (12/13) signalling events  REACT_18407  
NRAGE signals death through JNK  REACT_13638  
Rho GTPase cycle  REACT_11051  
 

Keywords

Molecular function 
Guanine-nucleotide releasing factor  definition   [KW-0344]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 27237
PRO: PR:Q5VV41