UBE2U - Ubiquitin-conjugating enzyme E2 U - human protein (Function)
 
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UBE2U »  Ubiquitin-conjugating enzyme E2 U   [ EC 6.3.2.19 ]
 
Protein also known as:  Ubiquitin carrier protein U.
Gene name:  UBE2U
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Catalyzes the covalent attachment of ubiquitin to other proteins.  
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  • PROSITE-ProRule
  • UniProtKB
GO molecular function 
Acid-amino acid ligase activitydefinition[GO:0016881] silver  
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  • InterPro 2 GO
ATP bindingdefinition[GO:0005524]  
1
  • UniProtKB KW
Small conjugating protein transferase activitydefinition[GO:0019787]  
1
  • RefGenome
Ubiquitin protein ligase activitydefinition[GO:0061630]  
1
  • RefGenome
Ubiquitin protein ligase bindingdefinition[GO:0031625]  
1
  • RefGenome
GO biological process 
DNA repairdefinition[GO:0006281]  
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  • RefGenome
Histone ubiquitinationdefinition[GO:0016574]  
1
  • RefGenome
Proteasome-mediated ubiquitin-dependent protein catabolic processdefinition[GO:0043161]  
1
  • RefGenome
Protein polyubiquitinationdefinition[GO:0000209]  
1
  • RefGenome
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 6.3.2.19: ATP + ubiquitin + protein lysine AMP + diphosphate + protein N-ubiquityllysine.  
3
  • PROSITE-ProRule
  • UniProtKB
Pathways 
This protein is involved in the following pathway
Protein modification; protein ubiquitination  
2
  • UniProtKB
  • PROSITE-ProRule
According to KEGG, this protein belongs to the following pathway:
Ubiquitin mediated proteolysis  hsa04120+148581  
According to Reactome, this protein belongs to the following pathway:
Antigen processing: Ubiquitination & Proteasome degradation  REACT_75842  
 

Keywords

Biological process 
Ubl conjugation pathway  definition   [KW-0833]
Molecular function 
Ligase  definition   [KW-0436]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 148581
PRO: PR:Q5VVX9