ANO1 - Anoctamin-1 - human protein (Function)
 
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ANO1 »  Anoctamin-1
 
Protein also known as:  Discovered on gastrointestinal stromal tumors protein 1.
Gene name:  ANO1
Family name: Anoctamin
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 84 3
GENE REF ISO

Function

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Overview 
Calcium-activated chloride channel (CaCC) which plays a role in transepithelial anion transport and smooth muscle contraction. Required for the normal functioning of the interstitial cells of Cajal (ICCs) which generate electrical pacemaker activity in gastrointestinal smooth muscles. Acts as a major contributor to basal and stimulated chloride conductance in airway epithelial cells and plays an important role in tracheal cartilage development.  
4
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the calcium-dependent chloride channel (ca-clc) family  1.A.17.1.1  
GO molecular function 
Calcium activated cation channel activitydefinition[GO:0005227]  
1
  • IDAUniProtKB
Intracellular calcium activated chloride channel activitydefinition[GO:0005229]  
3
  • IMPUniProtKB
  • ISSOrtholog Curator
Protein bindingdefinition[GO:0005515]  
1
  • IPIUniProtKB
GO biological process 
Cation transportdefinition[GO:0006812]  
1
  • IDAUniProtKB
Chloride transmembrane transportdefinition[GO:1902476]  
3
  • IMPGOC
  • IEAOrtholog Compara
  • ISSOrtholog Curator
  • IEAUniProtKB KW
Chloride transportdefinition[GO:0006821]  
1
  • IMPUniProtKB
  • ISSOrtholog Curator
Multicellular organismal developmentdefinition[GO:0007275]  
  • IEAUniProtKB KW
Regulation of membrane potentialdefinition[GO:0042391] silver  
  • IEAOrtholog Compara
Enzymatic activity 
It is regulated in the following manner
ATP and calmodulin are essential for its activation. Channel activity is inhibited by CFTR protein and by chloride inhibitors such as niflumic acid (NFA) and 4,4'-diisothiocyanatostilbene-2,2'-disulfonic acid (DIDS).  
1
  • CuratedUniProtKB
Pathways 
According to Reactome, this protein belongs to the following pathway:
Stimuli-sensing channels  REACT_160189  
Note 
The term 'anoctamin' was coined because these channels are anion selective and have eight (OCT) transmembrane segments. There is some dissatisfaction in the field with the Ano nomenclature because it is not certain that all the members of this family are anion channels or have the 8-transmembrane topology.  
  • CuratedUniProtKB
 

Keywords

Biological process 
Ion transport  definition   [KW-0406]
Transport  definition   [KW-0813]
Molecular function 
Chloride channel  definition   [KW-0869]
Developmental protein  definition   [KW-0217]
Ion channel  definition   [KW-0407]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: ANO1
GenomeRNAi: 55107
PRO: PR:Q5XXA6
Chemistry
GuidetoPHARMACOLOGY: 708