CD276 - CD276 antigen - human protein (Function)
 
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Protein
Gene
References

 
CD276 »  CD276 antigen
 
Protein also known as:  Costimulatory molecule; CD antigen CD276.
Gene name:  CD276
Family name: Immunoglobulin » BTN/MOG
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 74 4
GENE REF ISO

Function

 show evidences
Overview 
May participate in the regulation of T-cell-mediated immune response. May play a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells. May be involved in the development of acute and chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces. Could also play a key role in providing the placenta and fetus with a suitable immunological environment throughout pregnancy. Both isoform 1 and isoform 2 appear to be redundant in their ability to modulate CD4 T-cell responses.  
6
  • CuratedUniProtKB
Isoform  Iso 2   Is shown to enhance the induction of cytotoxic T-cells and selectively stimulates interferon gamma production in the presence of T-cell receptor signaling.  
6
  • CuratedUniProtKB
GO molecular function 
Protein bindingdefinition[GO:0005515]  
1
  • IPIUniProtKB
Receptor bindingdefinition[GO:0005102]  
1
  • NASHGNC
GO biological process 
Cell proliferationdefinition[GO:0008283]  
1
  • NASUniProtKB
Immune responsedefinition[GO:0006955]  
1
  • NASUniProtKB
Negative regulation of inflammatory responsedefinition[GO:0050728] silver  
  • IEAOrtholog Compara
Negative regulation of interferon-gamma biosynthetic processdefinition[GO:0045077] silver  
  • IEAOrtholog Compara
Negative regulation of interleukin-2 biosynthetic processdefinition[GO:0045085] silver  
  • IEAOrtholog Compara
Negative regulation of T cell proliferationdefinition[GO:0042130] silver  
  • IEAOrtholog Compara
Positive regulation of bone mineralizationdefinition[GO:0030501] silver  
  • IEAOrtholog Compara
Positive regulation of interferon-gamma biosynthetic processdefinition[GO:0045078]  
1
  • IDAHGNC
Positive regulation of osteoblast differentiationdefinition[GO:0045669] silver  
  • IEAOrtholog Compara
Positive regulation of T cell proliferationdefinition[GO:0042102]  
1
  • IDAHGNC
Regulation of immune responsedefinition[GO:0050776]  
1
  • NASHGNC
T cell activationdefinition[GO:0042110]  
1
  • IDAUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathway:
Cell adhesion molecules (CAMs)  hsa04514+80381  
Note 
B7-H3 locus underwent genomic duplication leading to tandemly repeated immunoglobulin-like V and C domains (VC domains). The dominantly expressed human B7-H3 isoform contains tandemly duplicated VC domains. In contrast, mouse B7-H3 transcript contains only one single VC domain form due to an exon structure corresponding to V domain-(pseudoexon C)-(pseudoexon V)-C domain. This duplication appearing in primates is suggested to be very recent supporting a model of multiple independent emergence of tandem VC repeats within human and monkey species.  
  • CuratedUniProtKB
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: CD276
GenomeRNAi: 80381
PRO: PR:Q5ZPR3