AFMID - Kynurenine formamidase - human protein (Function)
 
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AFMID »  Kynurenine formamidase   [ EC 3.5.1.9 ]  (KFA)
 
Protein also known as:  N-formylkynurenine formamidase (FKF).
Gene name:  AFMID
Family name: Kynurenine formamidase
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites (By similarity).  
  • CuratedUniProtKB
GO molecular function 
Arylformamidase activitydefinition[GO:0004061]  
  • IEAEC 2 GO
GO biological process 
'de novo' NAD biosynthetic process from tryptophandefinition[GO:0034354]  
  • IEAUniProtKB Annot
Tryptophan catabolic process to kynureninedefinition[GO:0019441]  
  • IEAUniPathway
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.5.1.9: N-formyl-L-kynurenine + H(2)O formate + L-kynurenine.  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathways:
Glyoxylate and dicarboxylate metabolism  hsa00630+125061  
Metabolic pathways  hsa01100+125061  
Tryptophan metabolism  hsa00380+125061  
According to Reactome, this protein belongs to the following pathway:
Metabolism  REACT_111217  
 

Keywords

Biological process 
Tryptophan catabolism  definition   [KW-0823]
Molecular function 
Hydrolase  definition   [KW-0378]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 125061
PRO: PR:Q63HM1