TENC1 - Tensin-like C1 domain-containing phosphatase - human protein (Function)
 
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TENC1 »  Tensin-like C1 domain-containing phosphatase   [ EC 3.1.3.- ]
 
Protein also known as:  C1 domain-containing phosphatase and tensin homolog (C1-TEN).
Gene name:  TENC1
Entry whose protein(s) existence is based on evidence at protein level
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1 36 5
GENE REF ISO

Function

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Overview 
Regulates cell motility and proliferation. May have phosphatase activity. Reduces AKT1 phosphorylation. Lowers AKT1 kinase activity and interferes with AKT1 signaling.  
1
  • CuratedUniProtKB
GO molecular function 
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Phosphoprotein phosphatase activitydefinition[GO:0004721]  
  • IEAUniProtKB KW
Protein bindingdefinition[GO:0005515]  
3
  • IPIUniProtKB
  • IPIIntAct
GO biological process 
Cellular homeostasisdefinition[GO:0019725] silver  
  • IEAOrtholog Compara
Collagen metabolic processdefinition[GO:0032963] silver  
  • IEAOrtholog Compara
Intracellular signal transductiondefinition[GO:0035556] silver  
  • IEAInterPro 2 GO
Kidney developmentdefinition[GO:0001822] silver  
  • IEAOrtholog Compara
Multicellular organism growthdefinition[GO:0035264] silver  
  • IEAOrtholog Compara
Multicellular organismal homeostasisdefinition[GO:0048871] silver  
  • IEAOrtholog Compara
Negative regulation of cell proliferationdefinition[GO:0008285]  
1
  • IMPUniProtKB
Response to muscle activitydefinition[GO:0014850] silver  
  • IEAOrtholog Compara
 

Keywords

Molecular function 
Hydrolase  definition   [KW-0378]
Protein phosphatase  definition   [KW-0904]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: TENC1
GenomeRNAi: 23371
PRO: PR:Q63HR2