TNS2 - Tensin-2 - human protein (Function)
 
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Protein
Gene
References

 
TNS2 »  Tensin-2   [ EC 3.1.3.- ]
 
Protein also known as:  C1 domain-containing phosphatase and tensin homolog (C1-TEN).
Gene name:  TNS2
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 44 5
GENE REF ISO

Function

 show evidences
Overview 
Regulates cell motility and proliferation. May have phosphatase activity. Reduces AKT1 phosphorylation. Lowers AKT1 kinase activity and interferes with AKT1 signaling.  
2
  • UniProtKB
GO molecular function 
Kinase bindingdefinition[GO:0019900]  
1
  • UniProtKB
Metal ion bindingdefinition[GO:0046872]  
1
  • UniProtKB KW
Phosphoprotein phosphatase activitydefinition[GO:0004721]  
1
  • UniProtKB KW
Protein bindingdefinition[GO:0005515]  
5
  • IntAct
  • UniProtKB
GO biological process 
Cellular homeostasisdefinition[GO:0019725] silver  
1
  • Ortholog Compara
Collagen metabolic processdefinition[GO:0032963] silver  
1
  • Ortholog Compara
Dephosphorylationdefinition[GO:0016311]  
1
  • UniProtKB KW
Intracellular signal transductiondefinition[GO:0035556] silver  
1
  • InterPro 2 GO
Kidney developmentdefinition[GO:0001822] silver  
1
  • Ortholog Compara
Multicellular organism growthdefinition[GO:0035264] silver  
1
  • Ortholog Compara
Multicellular organismal homeostasisdefinition[GO:0048871] silver  
1
  • Ortholog Compara
Negative regulation of cell proliferationdefinition[GO:0008285]  
1
  • UniProtKB
Response to muscle activitydefinition[GO:0014850] silver  
1
  • Ortholog Compara
 

Keywords

Molecular function 
Hydrolase  definition   [KW-0378]
Protein phosphatase  definition   [KW-0904]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: TENC1
GenomeRNAi: 23371
PRO: PR:Q63HR2