FAM21A - WASH complex subunit FAM21A - human protein (Function)
 
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FAM21A »  WASH complex subunit FAM21A
 
Gene name:  FAM21A
Family name: FAM21
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Component of the WASH complex, a complex present at the surface of endosomes that recruits and activates the Arp2/3 complex to induce actin polymerization. The WASH complex plays a key role in the fission of tubules that serve as transport intermediates during endosome sorting. In the complex, it probably mediates the recruitment of the complex to endosome membranes (By similarity).  
  • CuratedUniProtKB
GO biological process 
Retrograde transport, endosome to Golgidefinition[GO:0042147]  
  • ISSOrtholog Curator
Note 
In human, FAM21 has undergone evolutionary duplication, with 4 highly homologous family members existing, including FAM21A, FAM21B, FAM21C, and an N-terminally truncated FAM21D form.  
  • CuratedUniProtKB
 

Keywords

Biological process 
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 387680
PRO: PR:Q641Q2