ATG16L1 - Autophagy-related protein 16-1 - human protein (Function)
 
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Protein
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References

 
ATG16L1 »  Autophagy-related protein 16-1
 
Protein also known as:  APG16-like 1.
Gene name:  ATG16L1
Family name: WD repeat ATG16
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Plays an essential role in autophagy: interacts with ATG12-ATG5 to mediate the conjugation of phosphatidylethanolamine (PE) to LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C), to produce a membrane-bound activated form of LC3 named LC3-II. Thereby, controls the elongation of the nascent autophagosomal membrane.  
2
  • CuratedUniProtKB
GO molecular function 
Identical protein bindingdefinition[GO:0042802]  
2
  • IPIIntAct
Protein bindingdefinition[GO:0005515]  
3
  • IPIIntAct
GO biological process 
Autophagic vacuole assemblydefinition[GO:0000045]  
1
  • NASUniProtKB
Protein homooligomerizationdefinition[GO:0051260]  
1
  • NASUniProtKB
Protein transportdefinition[GO:0015031]  
  • IEAUniProtKB KW
 

Keywords

Biological process 
Autophagy  definition   [KW-0072]
Protein transport  definition   [KW-0653]
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ATG16L1
GenomeRNAi: 55054
PRO: PR:Q676U5