CREB3L3 - Cyclic AMP-responsive element-binding protein 3-like protein 3 - human protein (Function)
 
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CREB3L3 »  Cyclic AMP-responsive element-binding protein 3-like protein 3  (cAMP-responsive element-binding protein 3-like protein 3)
 
Protein also known as:  Transcription factor CREB-H. Cleaved into:  Processed cyclic AMP-responsive element-binding protein 3-like protein 3.
Gene name:  CREB3L3
Family name: bZIP » ATF
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Transcription factor that may act during endoplasmic reticulum stress by activating unfolded protein response target genes. Activated in response to cAMP stimulation. In vitro, binds to the cAMP response element (CRE) and box-B element. Activates transcription through box-B element. Activates transcription through CRE (By similarity). Seems to function synergistically with ATF6. In acute inflammatory response, may activate expression of acute phase response (APR) genes. May be involved in growth suppression.  
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  • UniProtKB
GO molecular function 
cAMP response element bindingdefinition[GO:0035497] silver  
1
  • InterPro 2 GO
Protein bindingdefinition[GO:0005515]  
1
  • IntAct
Protein heterodimerization activitydefinition[GO:0046982]  
1
  • ParkinsonsUK-UCL
Protein homodimerization activitydefinition[GO:0042803]  
1
  • ParkinsonsUK-UCL
RNA polymerase II regulatory region sequence-specific DNA bindingdefinition[GO:0000977]  
1
  • NTNU_SB
RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptiondefinition[GO:0001228]  
2
  • NTNU_SB
Transcription regulatory region sequence-specific DNA bindingdefinition[GO:0000976]  
1
  • ParkinsonsUK-UCL
GO biological process 
Endoplasmic reticulum unfolded protein responsedefinition[GO:0030968] silver  
1
  • InterPro 2 GO
Positive regulation of acute inflammatory responsedefinition[GO:0002675]  
1
  • ParkinsonsUK-UCL
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
1
  • NTNU_SB
Positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stressdefinition[GO:1990440]  
1
  • ParkinsonsUK-UCL
Transcription, DNA-templateddefinition[GO:0006351]  
1
  • UniProtKB KW
Pathways 
According to KEGG, this protein belongs to the following pathways:
Cholinergic synapse  hsa04725+84699  
Dopaminergic synapse  hsa04728+84699  
Huntington's disease  hsa05016+84699  
Melanogenesis  hsa04916+84699  
Prostate cancer  hsa05215+84699  
Vasopressin-regulated water reabsorption  hsa04962+84699  
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Unfolded protein response  definition   [KW-0834]
Molecular function 
Activator  definition   [KW-0010]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 84699
PRO: PR:Q68CJ9