ACSM2B - Acyl-coenzyme A synthetase ACSM2B, mitochondrial - human protein (Function)
 
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ACSM2B »  Acyl-coenzyme A synthetase ACSM2B, mitochondrial   [ EC 6.2.1.2 ]
 
Protein also known as:  Xenobiotic/medium-chain fatty acid-CoA ligase HXM-A.
Gene name:  ACSM2B
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Has medium-chain fatty acid:CoA ligase activity with broad substrate specificity (in vitro). Acts on acids from C(4) to C(11) and on the corresponding 3-hydroxy- and 2,3- or 3,4-unsaturated acids (in vitro).  
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  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Butyrate-CoA ligase activitydefinition[GO:0047760]  
  • IEAEC 2 GO
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
GO biological process 
Fatty acid metabolic processdefinition[GO:0006631]  
  • IEAUniProtKB KW
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 6.2.1.2: ATP + a carboxylate + CoA AMP + diphosphate + an acyl-CoA.  
  • CuratedUniProtKB
It requires the following cofactor
Magnesium or manganese.  
1
  • CuratedUniProtKB
It is regulated in the following manner
Activated by monovalent cations, such as potassium, rubidium or ammonium.  
1
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Butanoate metabolism  hsa00650+348158  
Metabolic pathways  hsa01100+348158  
According to Reactome, this protein belongs to the following pathway:
Metabolism  REACT_111217  
 

Keywords

Biological process 
Fatty acid metabolism  definition   [KW-0276]
Lipid metabolism  definition   [KW-0443]
Molecular function 
Ligase  definition   [KW-0436]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ACSM2B
GenomeRNAi: 348158
PRO: PR:Q68CK6