HGSNAT - Heparan-alpha-glucosaminide N-acetyltransferase - human protein (Function)
 
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Protein
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References

 
HGSNAT »  Heparan-alpha-glucosaminide N-acetyltransferase   [ EC 2.3.1.78 ]
 
Protein also known as:  Transmembrane protein 76.
Gene name:  HGSNAT
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Lysosomal acetyltransferase that acetylates the non-reducing terminal alpha-glucosamine residue of intralysosomal heparin or heparan sulfate, converting it into a substrate for luminal alpha-N-acetyl glucosaminidase.  
4
  • CuratedUniProtKB
GO molecular function 
Heparan-alpha-glucosaminide N-acetyltransferase activitydefinition[GO:0015019]  
  • IEAEC 2 GO
Transferase activity, transferring acyl groupsdefinition[GO:0016746]  
2
  • IDAUniProtKB
GO biological process 
Lysosomal transportdefinition[GO:0007041]  
1
  • IDAUniProtKB
Protein oligomerizationdefinition[GO:0051259]  
1
  • IDAUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.3.1.78: Acetyl-CoA + heparan sulfate alpha-D-glucosaminide CoA + heparan sulfate N-acetyl-alpha-D-glucosaminide.  
1
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Glycosaminoglycan degradation  hsa00531+138050  
Lysosome  hsa04142+138050  
Metabolic pathways  hsa01100+138050  
According to Reactome, this protein belongs to the following pathways:
Disease  REACT_116125  
Metabolism  REACT_111217  
Note 
A signal sequence is predicted but has been shown not to be cleaved in the reticulum endoplasmic.  
  • CuratedUniProtKB
 

Keywords

Molecular function 
Acyltransferase  definition   [KW-0012]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: Q68CP4
Other
GeneWiki: HGSNAT
GenomeRNAi: 138050
PRO: PR:Q68CP4