CDC42BPG - Serine/threonine-protein kinase MRCK gamma - human protein (Function)
 
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CDC42BPG »  Serine/threonine-protein kinase MRCK gamma   [ EC 2.7.11.1 ]
 
Protein also known as:  Myotonic dystrophy kinase-related CDC42-binding kinase gamma (MRCKG).
Gene name:  CDC42BPG
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
May act as a downstream effector of CDC42 in cytoskeletal reorganization. Contributes to the actomyosin contractility required for cell invasion, through the regulation of MYPT1 and thus MLC2 phosphorylation (By similarity).  
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  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
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  • IDAUniProtKB
Magnesium ion bindingdefinition[GO:0000287]  
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  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
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  • IPIIntAct
Protein serine/threonine kinase activitydefinition[GO:0004674]  
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  • IDAUniProtKB
Small GTPase regulator activitydefinition[GO:0005083] silver  
  • IEAInterPro 2 GO
GO biological process 
Actin cytoskeleton reorganizationdefinition[GO:0031532]  
  • ISSOrtholog Curator
Intracellular signal transductiondefinition[GO:0035556] silver  
  • IEAInterPro 2 GO
Protein phosphorylationdefinition[GO:0006468]  
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  • IDAUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.1: ATP + a protein ADP + a phosphoprotein.  
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  • CuratedUniProtKB
It requires the following cofactor
Magnesium.  
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  • CuratedUniProtKB
It is regulated in the following manner
Maintained in an inactive, closed conformation by an interaction between the kinase domain and the negative autoregulatory C-terminal coiled-coil region. Agonist binding to the phorbol ester binding site disrupts this, releasing the kinase domain to allow N-terminus-mediated dimerization and kinase activation by transautophosphorylation (By similarity).  
  • CuratedUniProtKB
 

Keywords

Molecular function 
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GenomeRNAi: 55561
PRO: PR:Q6DT37
Chemistry
GuidetoPHARMACOLOGY: 1506