AWAT2 - Acyl-CoA wax alcohol acyltransferase 2 - human protein (Function)
 
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Protein
Gene
References

 
AWAT2 »  Acyl-CoA wax alcohol acyltransferase 2   [ EC 2.3.1.75 ]
 
Protein also known as:  Diacylglycerol O-acyltransferase 2-like protein 4.
Gene name:  AWAT2
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Acyltransferase that predominantly esterify long chain (wax) alcohols with acyl-CoA-derived fatty acids to produce wax esters. Wax esters are enriched in sebum, suggesting that it plays a central role in lipid metabolism in skin. Has no activity using decyl alcohol and significantly prefers the C16 and C18 alcohols. May also have 2-acylglycerol O-acyltransferase (MGAT) and acyl-CoA:retinol acyltransferase (ARAT) activities, to catalyze the synthesis of diacylglycerols and retinyl esters; however this activity is unclear in vivo.  
3
  • CuratedUniProtKB
GO molecular function 
Long-chain-alcohol O-fatty-acyltransferase activitydefinition[GO:0047196]  
  • IEAEC 2 GO
Retinol O-fatty-acyltransferase activitydefinition[GO:0050252]  
  • IEAEC 2 GO
GO biological process 
Retinol metabolic processdefinition[GO:0042572]  
  • IEAEC 2 GO
Wax biosynthetic processdefinition[GO:0010025] silver  
  • IEAOrtholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reactions
EC 2.3.1.75: Acyl-CoA + a long-chain alcohol CoA + a long-chain ester.  
1
  • CuratedUniProtKB
EC 2.3.1.76: Acyl-CoA + retinol CoA + retinyl ester.  
1
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Retinol metabolism  hsa00830+158835  
Vitamin digestion and absorption  hsa04977+158835  
 

Biophysicochemical properties

Kinetic parameters
Vmax 1232 pmol/min/mg enzyme with [14C]cetyl-CoA as substrate

Keywords

Biological process 
Lipid biosynthesis  definition   [KW-0444]
Lipid metabolism  definition   [KW-0443]
Molecular function 
Acyltransferase  definition   [KW-0012]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 158835
PRO: PR:Q6E213