OTUD7B - OTU domain-containing protein 7B - human protein (Function)
 
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OTUD7B »  OTU domain-containing protein 7B   [ EC 3.4.19.12 ]
 
Protein also known as:  Cellular zinc finger anti-NF-kappa-B protein.
Gene name:  OTUD7B
Family name: Peptidase C64
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Negative regulator of the non-canonical NF-kappa-B pathway that acts by mediating deubiquitination of TRAF3, an inhibitor of the NF-kappa-B pathway, thereby acting as a negative regulator of B-cell responses. In response to non-canonical NF-kappa-B stimuli, deubiquitinates 'Lys-48'-linked polyubiquitin chains of TRAF3, preventing TRAF3 proteolysis and over-activation of non-canonical NF-kappa-B. Negatively regulates mucosal immunity against infections. Mediates deubiquitination of EGFR. Has deubiquitinating activity toward 'Lys-11', 'Lys-48' or 'Lys-63'-linked polyubiquitin chains. In vitro, has preference for 'Lys-11'-linked polyubiquitin chains; however such data are unsure in vivo. Hydrolyzes both linear and branched forms of polyubiquitin.  
6
  • CuratedUniProtKB
GO molecular function 
Cysteine-type peptidase activitydefinition[GO:0008234]  
  • ISSOrtholog Curator
DNA bindingdefinition[GO:0003677] silver  
  • IEAInterPro 2 GO
K63-linked polyubiquitin bindingdefinition[GO:0070530] silver  
  • IEAOrtholog Compara
Protein bindingdefinition[GO:0005515]  
3
  • IPIIntAct
  • IPIHGNC
Ubiquitin thiolesterase activitydefinition[GO:0004221]  
  • ISSOrtholog Curator
Ubiquitin-specific protease activitydefinition[GO:0004843]  
1
  • IDAUniProtKB
Zinc ion bindingdefinition[GO:0008270] silver  
  • IEAInterPro 2 GO
GO biological process 
Mucosal immune responsedefinition[GO:0002385]  
  • ISSOrtholog Curator
Negative regulation of I-kappaB kinase/NF-kappaB signalingdefinition[GO:0043124]  
1
  • IDAHGNC
Protein K11-linked deubiquitinationdefinition[GO:0035871]  
2
  • IDAUniProtKB
Protein K48-linked deubiquitinationdefinition[GO:0071108]  
  • ISSOrtholog Curator
Protein K63-linked deubiquitinationdefinition[GO:0070536]  
1
  • IDAUniProtKB
Proteolysisdefinition[GO:0006508]  
  • IEAUniProtKB KW
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.4.19.12: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).  
1
  • CuratedUniProtKB
It is regulated in the following manner
Deubiquitinase activity is inhibited following interactin with PARK7.  
1
  • CuratedUniProtKB
 
More information is available from:
 

Keywords

Biological process 
Immunity  definition   [KW-0391]
Ubl conjugation pathway  definition   [KW-0833]
Molecular function 
Hydrolase  definition   [KW-0378]
Protease  definition   [KW-0645]
Thiol protease  definition   [KW-0788]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: OTUD7B
GenomeRNAi: 56957
PRO: PR:Q6GQQ9