SMEK1 - Serine/threonine-protein phosphatase 4 regulatory subunit 3A - human protein (Function)
 
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SMEK1 »  Serine/threonine-protein phosphatase 4 regulatory subunit 3A
 
Protein also known as:  SMEK homolog 1.
Gene name:  SMEK1
Family name: SMEK
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 33 4
GENE REF ISO

Function

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Overview 
Regulatory subunit of serine/threonine-protein phosphatase 4. May regulate the activity of PPP4C at centrosomal microtubule organizing centers. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on 'Ser-140' (gamma-H2AFX) generated during DNA replication and required for DNA DSB repair.  
1
  • CuratedUniProtKB
GO biological process 
Positive regulation of gluconeogenesisdefinition[GO:0045722] silver  
  • IEAOrtholog Compara
Protein dephosphorylationdefinition[GO:0006470] silver  
  • IEAOrtholog Compara
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 55671
PRO: PR:Q6IN85