SPOPL - Speckle-type POZ protein-like - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
SPOPL »  Speckle-type POZ protein-like
 
Protein also known as:  Roadkill homolog 2.
Gene name:  SPOPL
Family name: Tdpoz
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 12 1
GENE REF ISO

Function

 show evidences
Overview 
Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, but with relatively low efficiency. Cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes containing homodimeric SPOPL or the heterodimer formed by SPOP and SPOPL are less efficient than ubiquitin ligase complexes containing only SPOP. May function to down-regulate the activity of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that contain SPOP.  
1
  • CuratedUniProtKB
GO biological process 
Negative regulation of protein ubiquitinationdefinition[GO:0031397]  
1
  • IMPUniProtKB
Proteasome-mediated ubiquitin-dependent protein catabolic processdefinition[GO:0043161]  
1
  • IMPUniProtKB
Protein ubiquitinationdefinition[GO:0016567]  
  • IEAUniPathway
Pathways 
This protein is involved in the following pathway
 

Keywords

Biological process 
Ubl conjugation pathway  definition   [KW-0833]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 339745
PRO: PR:Q6IQ16