TTBK2 - Tau-tubulin kinase 2 - human protein (Function)
 
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References

 
TTBK2 »  Tau-tubulin kinase 2   [ EC 2.7.11.1 ]
 
Gene name:  TTBK2
Entry whose protein(s) existence is based on evidence at protein level
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1 33 3
GENE REF ISO

Function

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Overview 
Serine/threonine kinase that acts as a key regulator of ciliogenesis: controls the initiation of ciliogenesis by binding to the distal end of the basal body and promoting the removal of CCP110, which caps the mother centriole, leading to the recruitment of IFT proteins, which build the ciliary axoneme. Has some substrate preference for proteins that are already phosphorylated on a Tyr residue at the +2 position relative to the phosphorylation site. Able to phosphorylate tau on serines in vitro.  
2
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
Protein serine/threonine kinase activitydefinition[GO:0004674]  
1
  • IDAUniProtKB
GO biological process 
Cell deathdefinition[GO:0008219]  
  • IEAUniProtKB KW
Cilium assemblydefinition[GO:0042384]  
  • ISSOrtholog Curator
Peptidyl-serine phosphorylationdefinition[GO:0018105]  
1
  • IDAUniProtKB
Smoothened signaling pathwaydefinition[GO:0007224]  
  • ISSOrtholog Curator
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.1: ATP + a protein ADP + a phosphoprotein.  
1
  • CuratedUniProtKB
 

Biophysicochemical properties

Kinetic parameters
KM 141 uM for RRKDLHDDEEDEAMSIYA peptide
KM 18 uM for RRKDLHDDEEDEAMSIYpA peptide
Vmax 66 umol/min/mg enzyme with RRKDLHDDEEDEAMSIYA peptide as substrate
Vmax 76 umol/min/mg enzyme with RRKDLHDDEEDEAMSIYpA peptide as substrate

Keywords

Biological process 
Cilium biogenesis/degradation  definition   [KW-0970]
Molecular function 
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: TTBK2
GenomeRNAi: 146057
PRO: PR:Q6IQ55