GDF6 - Growth/differentiation factor 6 - human protein (Function)
 
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GDF6 »  Growth/differentiation factor 6  (GDF-6)
 
Protein also known as:  Growth/differentiation factor 16.
Gene name:  GDF6
Family name: TGF-beta
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Growth factor that controls proliferation and cellular differentiation in the retina and bone formation. Plays a key role in regulating apoptosis during retinal development. Establishes dorsal-ventral positional information in the retina and controls the formation of the retinotectal map. Required for normal formation of bones and joints in the limbs, skull, and axial skeleton. Plays a key role in establishing boundaries between skeletal elements during development. May signal through the growth factor receptors subunits BMPR1A, BMPR1B, BMPR2 and ACVR2A.  
1
  • CuratedUniProtKB
GO molecular function 
Cytokine activitydefinition[GO:0005125]  
  • IEAUniProtKB KW
Growth factor activitydefinition[GO:0008083]  
  • IEAUniProtKB KW
Protein homodimerization activitydefinition[GO:0042803] silver  
  • IEAOrtholog Compara
GO biological process 
Activin receptor signaling pathwaydefinition[GO:0032924]  
1
  • IDABHF-UCL
Apoptotic processdefinition[GO:0006915]  
  • ISSOrtholog Curator
BMP signaling pathwaydefinition[GO:0030509]  
1
  • IDABHF-UCL
Growthdefinition[GO:0040007] silver  
  • IEAInterPro 2 GO
Pathway-restricted SMAD protein phosphorylationdefinition[GO:0060389]  
1
  • IDABHF-UCL
Positive regulation of neuron differentiationdefinition[GO:0045666] silver  
  • IEAOrtholog Compara
Positive regulation of pathway-restricted SMAD protein phosphorylationdefinition[GO:0010862]  
1
  • IDABHF-UCL
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
1
  • IDABHF-UCL
Retinal cell apoptotic processdefinition[GO:1990009]  
  • ISSOrtholog Curator
Pathways 
According to KEGG, this protein belongs to the following pathway:
TGF-beta signaling pathway  hsa04350+392255  
 

Keywords

Biological process 
Apoptosis  definition   [KW-0053]
Molecular function 
Cytokine  definition   [KW-0202]
Developmental protein  definition   [KW-0217]
Growth factor  definition   [KW-0339]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: GDF6
GenomeRNAi: 392255
PRO: PR:Q6KF10