B4GALNT3 - Beta-1,4-N-acetylgalactosaminyltransferase 3 - human protein (Function)
 
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Protein
Gene
References

 
B4GALNT3 »  Beta-1,4-N-acetylgalactosaminyltransferase 3   [ EC 2.4.1.244 ]  (B4GalNAcT3)
 
Protein also known as:  N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase 2 (NGalNAc-T2).
Gene name:  B4GALNT3
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

 show evidences
Overview 
Transfers N-acetylgalactosamine (GalNAc) from UDP-GalNAc to N-acetylglucosamine-beta-benzyl with a beta-1,4-linkage to form N,N'-diacetyllactosediamine, GalNAc-beta-1,4-GlcNAc structures in N-linked glycans and probably O-linked glycans. Mediates the N,N'-diacetyllactosediamine formation on gastric mucosa.  
1
  • CuratedUniProtKB
GO molecular function 
Acetylgalactosaminyltransferase activitydefinition[GO:0008376]  
1
  • IDAHGNC
N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activitydefinition[GO:0033842]  
  • IEAEC 2 GO
GO biological process 
Metabolic processdefinition[GO:0008152]  
1
  • IDAGOC
  • IEAEC 2 GO
  • IEAUniProtKB KW
  • IEAInterPro 2 GO
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.4.1.244: UDP-N-acetyl-alpha-D-galactosamine + N-acetyl-beta-D-glucosaminyl group UDP + N-acetyl-beta-D-galactosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl group.  
1
  • CuratedUniProtKB
According to CAZy, this protein is belongs to the following pathway:
Glycosyltransferase Family 7  GT7  
 
More information is available from:
 

Keywords

Molecular function 
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 283358
PRO: PR:Q6L9W6