ALKBH2 - Alpha-ketoglutarate-dependent dioxygenase alkB homolog 2 - human protein (Function)
 
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ALKBH2 »  Alpha-ketoglutarate-dependent dioxygenase alkB homolog 2   [ EC 1.14.11.33 ]
 
Protein also known as:  Alkylated DNA repair protein alkB homolog 2.
Gene name:  ALKBH2
Family name: AlkB
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 27 2
GENE REF ISO

Function

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Overview 
Dioxygenase that repairs alkylated DNA and RNA containing 1-methyladenine and 3-methylcytosine by oxidative demethylation. Can also repair alkylated DNA containing 1-ethenoadenine (in vitro). Has strong preference for double-stranded DNA. Has low efficiency with single-stranded substrates. Requires molecular oxygen, alpha-ketoglutarate and iron.  
5
  • CuratedUniProtKB
GO molecular function 
Cytosine C-5 DNA demethylase activitydefinition[GO:0051747]  
2
  • TASBHF-UCL
  • IDAUniProtKB
DNA-N1-methyladenine dioxygenase activitydefinition[GO:0043734]  
1
  • IDAUniProtKB
Ferrous iron bindingdefinition[GO:0008198]  
1
  • IDAUniProtKB
GO biological process 
DNA dealkylation involved in DNA repairdefinition[GO:0006307]  
2
  • TASBHF-UCL
  • IDAUniProtKB
DNA demethylationdefinition[GO:0080111]  
1
  • TASBHF-UCL
Oxidative demethylationdefinition[GO:0070989]  
1
  • TASBHF-UCL
Oxidative DNA demethylationdefinition[GO:0035511]  
1
  • IDAUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 1.14.11.33: DNA-base-CH(3) + 2-oxoglutarate + O(2) DNA-base + formaldehyde + succinate + CO(2).  
  • CuratedUniProtKB
It requires the following cofactor
Binds 1 Fe(2+) ion per subunit.  
2
  • CuratedUniProtKB
It is regulated in the following manner
Activated by ascorbate and magnesium ions.  
2
  • CuratedUniProtKB
Pathways 
According to Reactome, this protein belongs to the following pathway:
ABH2 mediated Reversal of Alkylation Damage  REACT_526  
 

Keywords

Biological process 
DNA damage  definition   [KW-0227]
DNA repair  definition   [KW-0234]
Molecular function 
Dioxygenase  definition   [KW-0223]
Oxidoreductase  definition   [KW-0560]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 121642
PRO: PR:Q6NS38