MAST2 - Microtubule-associated serine/threonine-protein kinase 2 - human protein (Function)
 
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MAST2 »  Microtubule-associated serine/threonine-protein kinase 2   [ EC 2.7.11.1 ]
 
Gene name:  MAST2
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins. Functions in a multi-protein complex in spermatid maturation. Regulates lipopolysaccharide-induced IL-12 synthesis in macrophages by forming a complex with TRAF6, resulting in the inhibition of TRAF6 NF-kappa-B activation (By similarity).  
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • ISSOrtholog Curator
Magnesium ion bindingdefinition[GO:0000287]  
  • ISSOrtholog Curator
Microtubule bindingdefinition[GO:0008017] silver  
  • IEAOrtholog Compara
Phosphatase bindingdefinition[GO:0019902]  
1
  • IPIUniProtKB
Protein bindingdefinition[GO:0005515]  
2
  • IPIIntAct
Protein serine/threonine kinase activitydefinition[GO:0004674] silver  
  • IEAOrtholog Compara
GO biological process 
Protein phosphorylationdefinition[GO:0006468]  
  • ISSOrtholog Curator
Regulation of interleukin-12 biosynthetic processdefinition[GO:0045075]  
  • ISSOrtholog Curator
Spermatid differentiationdefinition[GO:0048515]  
  • ISSOrtholog Curator
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.1: ATP + a protein ADP + a phosphoprotein.  
  • CuratedUniProtKB
It requires the following cofactor
Magnesium (By similarity).  
  • CuratedUniProtKB
 

Keywords

Molecular function 
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: MAST2
GenomeRNAi: 23139
PRO: PR:Q6P0Q8