SLC27A4 - Long-chain fatty acid transport protein 4 - human protein (Function)
 
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SLC27A4 »  Long-chain fatty acid transport protein 4   [ EC 6.2.1.- ]  (FATP-4)
 
Protein also known as:  Solute carrier family 27 member 4.
Gene name:  SLC27A4
Entry whose protein(s) existence is based on evidence at protein level
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1 25 1
GENE REF ISO

Function

 show evidences
Overview 
Involved in translocation of long-chain fatty acids (LFCA) across the plasma membrane. Appears to be the principal fatty acid transporter in small intestinal enterocytes. Plays a role in the formation of the epidermal barrier. Required for fat absorption in early embryogenesis. Has acyl-CoA ligase activity for long-chain and very-long-chain fatty acids (VLCFAs). Indirectly inhibits RPE65 via substrate competition and via production of VLCFA derivatives like lignoceroyl-CoA. Prevents light-induced degeneration of rods and cones (By similarity).  
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the proposed fatty acid transporter (fat) family  4.C.1.1.10  
GO molecular function 
Fatty acid transporter activitydefinition[GO:0015245]  
1
  • TASPINC
Long-chain fatty acid-CoA ligase activitydefinition[GO:0004467]  
1
  • IDAUniProtKB
Nucleotide bindingdefinition[GO:0000166]  
  • IEAUniProtKB KW
Very long-chain fatty acid-CoA ligase activitydefinition[GO:0031957] silver  
  • IEAOrtholog Compara
GO biological process 
Fatty acid transportdefinition[GO:0015908]  
1
  • TASPINC
Lipid metabolic processdefinition[GO:0006629]  
1
  • TASPINC
Long-chain fatty acid importdefinition[GO:0044539]  
1
  • IDAUniProtKB
Long-chain fatty acid metabolic processdefinition[GO:0001676]  
1
  • IDAUniProtKB
Medium-chain fatty acid transportdefinition[GO:0001579] silver  
  • IEAOrtholog Compara
Response to nutrientdefinition[GO:0007584] silver  
  • IEAOrtholog Compara
Skin developmentdefinition[GO:0043588] silver  
  • IEAOrtholog Compara
Transportdefinition[GO:0006810]  
1
  • TASPINC
Very long-chain fatty acid catabolic processdefinition[GO:0042760] silver  
  • IEAOrtholog Compara
Enzymatic activity 
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Fat digestion and absorption  hsa04975+10999  
PPAR signaling pathway  hsa03320+10999  
According to Reactome, this protein belongs to the following pathway:
Transmembrane transport of small molecules  REACT_15518  
Note 
SLC27A4/FATP4-mediated fatty acid uptake is associated to paramaters related to insulin resistance, which is associated with disturbed fatty acid metabolism and homeostasis, such as obesity. SLC27A4/FATP4 expression is positively correlated with acquired obesity.  
  • CuratedUniProtKB
 

Keywords

Biological process 
Fatty acid metabolism  definition   [KW-0276]
Lipid metabolism  definition   [KW-0443]
Lipid transport  definition   [KW-0445]
Transport  definition   [KW-0813]
Molecular function 
Ligase  definition   [KW-0436]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: SLC27A4
GenomeRNAi: 10999
PRO: PR:Q6P1M0