PKN3 - Serine/threonine-protein kinase N3 - human protein (Function)
 
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PKN3 »  Serine/threonine-protein kinase N3   [ EC 2.7.11.13 ]
 
Protein also known as:  Protein-kinase C-related kinase 3.
Gene name:  PKN3
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Contributes to invasiveness in malignant prostate cancer.  
1
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
Protein kinase activitydefinition[GO:0004672]  
1
  • TASPINC
Protein kinase C activitydefinition[GO:0004697]  
  • IEAEC 2 GO
GO biological process 
Epithelial cell migrationdefinition[GO:0010631]  
1
  • IDAUniProtKB
Protein phosphorylationdefinition[GO:0006468]  
1
  • TASPINC
Signal transductiondefinition[GO:0007165] silver  
  • IEAInterPro 2 GO
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.13: ATP + a protein ADP + a phosphoprotein.  
  • CuratedUniProtKB
It is regulated in the following manner
Two specific sites, Thr-718 (activation loop of the kinase domain) and Thr-860 (turn motif), need to be phosphorylated for its full activation (By similarity).  
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathway:
Salmonella infection  hsa05132+29941  
 

Keywords

Molecular function 
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: PKN3_(gene)
GenomeRNAi: 29941
PRO: PR:Q6P5Z2