PSRC1 - Proline/serine-rich coiled-coil protein 1 - human protein (Function)
 
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Protein
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PSRC1 »  Proline/serine-rich coiled-coil protein 1
 
Gene name:  PSRC1
Family name: PSRC1
Entry whose protein(s) existence is based on evidence at protein level
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1 35 4
GENE REF ISO

Function

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Overview 
Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate, and for normal rate of chromosomal segregation during anaphase. Plays a role in the regulation of mitotic spindle dynamics. Increases the rate of turnover of microtubules on metaphase spindles, and contributes to the generation of normal tension across sister kinetochores. Recruits KIF2A to the mitotic spindle and spindle poles. May participate in p53/TP53-regulated growth suppression.  
2
  • CuratedUniProtKB
GO molecular function 
Microtubule bindingdefinition[GO:0008017]  
1
  • ISSBHF-UCL
Protein bindingdefinition[GO:0005515]  
1
  • IPIUniProtKB
GO biological process 
Microtubule bundle formationdefinition[GO:0001578]  
1
  • ISSBHF-UCL
Mitotic metaphase plate congressiondefinition[GO:0007080]  
1
  • IDAUniProtKB
Negative regulation of cell growthdefinition[GO:0030308]  
1
  • ISSBHF-UCL
Positive regulation of cyclin-dependent protein serine/threonine kinase activitydefinition[GO:0045737]  
1
  • ISSBHF-UCL
Positive regulation of microtubule polymerizationdefinition[GO:0031116]  
1
  • ISSBHF-UCL
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
1
  • ISSBHF-UCL
Regulation of mitotic spindle organizationdefinition[GO:0060236]  
1
  • IDAUniProtKB
 

Keywords

Biological process 
Cell cycle  definition   [KW-0131]
Cell division  definition   [KW-0132]
Mitosis  definition   [KW-0498]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: PSRC1
GenomeRNAi: 84722
PRO: PR:Q6PGN9