DARS2 - Aspartate--tRNA ligase, mitochondrial - human protein (Function)
 
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Protein
Gene
References

 
DARS2 »  Aspartate--tRNA ligase, mitochondrial   [ EC 6.1.1.12 ]
 
Protein also known as:  Aspartyl-tRNA synthetase (AspRS).
Gene name:  DARS2
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 33 1
GENE REF ISO

Function

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GO molecular function 
Aspartate-tRNA(Asn) ligase activitydefinition[GO:0050560]  
2
  • IDABHF-UCL
ATP bindingdefinition[GO:0005524]  
1
  • TASBHF-UCL
Protein bindingdefinition[GO:0005515]  
1
  • IPIBHF-UCL
Protein homodimerization activitydefinition[GO:0042803]  
1
  • IPIBHF-UCL
tRNA bindingdefinition[GO:0000049]  
1
  • TASBHF-UCL
GO biological process 
Mitochondrial asparaginyl-tRNA aminoacylationdefinition[GO:0070145]  
1
  • ICBHF-UCL
tRNA aminoacylationdefinition[GO:0043039]  
2
  • IDABHF-UCL
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 6.1.1.12: ATP + L-aspartate + tRNA(Asp) AMP + diphosphate + L-aspartyl-tRNA(Asp).  
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathway:
Aminoacyl-tRNA biosynthesis  hsa00970+55157  
According to Reactome, this protein belongs to the following pathway:
Mitochondrial tRNA aminoacylation  REACT_15302  
 

Keywords

Biological process 
Protein biosynthesis  definition   [KW-0648]
Molecular function 
Aminoacyl-tRNA synthetase  definition   [KW-0030]
Ligase  definition   [KW-0436]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 55157
PRO: PR:Q6PI48