KCNIP4 - Kv channel-interacting protein 4 - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Protein
Gene
References

 
KCNIP4 »  Kv channel-interacting protein 4  (KChIP4)
 
Protein also known as:  A-type potassium channel modulatory protein 4.
Gene name:  KCNIP4
Family name: Recoverin
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 27 5
GENE REF ISO

Function

 show evidences
Overview 
Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Modulates KCND2 channel density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner (PubMed11847232, PubMed18957440, PubMed23576435). Modulates KCND3/Kv4.3 currents (PubMed23576435).  
4
  • UniProtKB
Isoform  Iso 4   Retains KCND3 in the endoplasmic reticulum and negatively regulates its expression at the cell membrane.  
5
  • UniProtKB
Isoform  Iso 4   Does not increase KCND2 expression at the cell membrane (PubMed18957440).  
4
  • UniProtKB
According to TCDB this is a transporter from family:
the phagocyte (gp91(phox)) nadph oxidase family  5.B.1.1.7  
GO molecular function 
Calcium ion bindingdefinition[GO:0005509]  
1
  • UniProtKB
Potassium channel activitydefinition[GO:0005267]  
1
  • UniProtKB KW
Potassium channel regulator activitydefinition[GO:0015459]  
1
  • Ortholog Curator
Voltage-gated ion channel activitydefinition[GO:0005244]  
1
  • UniProtKB KW
GO biological process 
Potassium ion transmembrane transportdefinition[GO:0071805]  
1
  • UniProtKB KW
Protein localization to plasma membranedefinition[GO:0072659]  
1
  • Ortholog Curator
Regulation of potassium ion transmembrane transportdefinition[GO:1901379]  
1
  • Ortholog Curator
 

Keywords

Biological process 
Ion transport  definition   [KW-0406]
Potassium transport  definition   [KW-0633]
Transport  definition   [KW-0813]
Molecular function 
Ion channel  definition   [KW-0407]
Potassium channel  definition   [KW-0631]
Voltage-gated channel  definition   [KW-0851]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 80333
PRO: PR:Q6PIL6